During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …

Aging leads to numerous changes that affect all physiological systems of the body including
the immune system, causing greater susceptibility to infectious disease and contributing to …

The transfer of high-avidity T cell receptor (TCR) genes isolated from rare tumor-specific
lymphocytes into polyclonal T cells is an attractive cancer immunotherapy strategy …

A major challenge of cancer immunotherapy is to develop delivery strategies that can
effectively and safely augment the immune system's antitumor response. Here, we report on …

Abstract Purpose: Upregulation of CD137 (4-1BB) on recently activated CD8+ T cells has
been used to identify rare viral or tumor antigen-specific T cells from peripheral blood. Here …

MICA molecules interact with the NKG2D-activating receptor on human NK and CD8 T cells.
We investigated the participation of the MICA/NKG2D pathway in the destruction of intestinal …

T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-
primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling …

Memory CD8+ T cells induced upon immunization exhibit improved functional features that
contribute to protection of immunized hosts. Although both cognate antigen recognition and …

IL-15 has substantial potential as an immunotherapeutic agent for augmenting immune
responses. However, the activity of IL-15 is mediated by a unique mechanism in which the …

Villitis of unknown etiology (VUE) is an important pattern of placental injury occurring
predominantly in term placentas. Although overlapping with infectious villitis, its clinical and …