Patterning of the cell cortex by Rho GTPases
Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …
that regulate basic biological processes such as cell locomotion, cell division and …
Anillin is an emerging regulator of tumorigenesis, acting as a cortical cytoskeletal scaffold and a nuclear modulator of cancer cell differentiation
Remodeling of the intracellular cytoskeleton plays a key role in accelerating tumor growth
and metastasis. Targeting different cytoskeletal elements is important for existing and future …
and metastasis. Targeting different cytoskeletal elements is important for existing and future …
Anillin promotes cell contractility by cyclic resetting of RhoA residence kinetics
RhoA stimulates cell contractility by recruiting downstream effectors to the cortical plasma
membrane. We now show that direct binding by anillin is required for effective signaling: this …
membrane. We now show that direct binding by anillin is required for effective signaling: this …
Rho flares repair local tight junction leaks
Tight junctions contribute to epithelial barrier function by selectively regulating the quantity
and type of molecules that cross the paracellular barrier. Experimental approaches to …
and type of molecules that cross the paracellular barrier. Experimental approaches to …
Effector-mediated ERM activation locally inhibits RhoA activity to shape the apical cell domain
Activated ezrin-radixin-moesin (ERM) proteins link the plasma membrane to the actin
cytoskeleton to generate apical structures, including microvilli. Among many kinases …
cytoskeleton to generate apical structures, including microvilli. Among many kinases …
Mechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling
S Varadarajan, SA Chumki, RE Stephenson… - Journal of Cell …, 2022 - rupress.org
Epithelial cell–cell junctions remodel in response to mechanical stimuli to maintain barrier
function. Previously, we found that local leaks in tight junctions (TJs) are rapidly repaired by …
function. Previously, we found that local leaks in tight junctions (TJs) are rapidly repaired by …
Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis
K Yamamoto, H Miura, M Ishida, Y Mii… - Nature …, 2021 - nature.com
Actomyosin contractility generated cooperatively by nonmuscle myosin II and actin filaments
plays essential roles in a wide range of biological processes, such as cell motility …
plays essential roles in a wide range of biological processes, such as cell motility …
Anillin propels myosin-independent constriction of actin rings
O Kučera, V Siahaan, D Janda, SH Dijkstra… - Nature …, 2021 - nature.com
Constriction of the cytokinetic ring, a circular structure of actin filaments, is an essential step
during cell division. Mechanical forces driving the constriction are attributed to myosin motor …
during cell division. Mechanical forces driving the constriction are attributed to myosin motor …
PDZD-8 and TEX-2 regulate endosomal PI(4,5)P2 homeostasis via lipid transport to promote embryogenesis in C. elegans
Different types of cellular membranes have unique lipid compositions that are important for
their functional identity. PI (4, 5) P2 is enriched in the plasma membrane where it contributes …
their functional identity. PI (4, 5) P2 is enriched in the plasma membrane where it contributes …
Developing molecular classifiers to detect environmental stressors, smolt stages and morbidity in coho salmon, Oncorhynchus kisutch
A Akbarzadeh, TJ Ming, AD Schulze… - Science of the Total …, 2024 - Elsevier
Aquatic species are increasingly confronted with environmental stressors because of climate
change. Although molecular technologies have advanced our understanding of how …
change. Although molecular technologies have advanced our understanding of how …