Despite advances in clinical practice, local anaesthetic systemic toxicity continues to occur
with the therapeutic use of local anaesthesia. Patterns of presentation have evolved over …

Background Weinberg et al. 1 first showed in 1998 that an infusion of a soybean oil
emulsion normally used as a total parenteral nutrition solution could prevent (by …

Introduction Emergency clinicians utilize local anesthetics for a variety of procedures in the
emergency department (ED) setting. Local anesthetic systemic toxicity (LAST) is a potentially …

The experimental use of lipid emulsion for local anesthetic toxicity was originally identified in
1998. It was then translated to clinical practice in 2006 and expanded to drugs other than …

Lipid emulsion has been shown to be an effective treatment for systemic toxicity induced by
local anesthetics, which is reflected in case reports. A systemic review and meta-analysis …

Currently, lipid emulsion (LE) is widely used to treat local anesthetic systemic toxicity (LAST).
LE also ameliorates intractable cardiovascular collapse caused by lipid-soluble non-local …

Objectives: Bolus infusion of lipid emulsion can reverse cardiac pharmacotoxicity caused by
local anesthetics and other lipophilic drugs. The mechanisms of this effect are not …

Triglyceride micro-emulsions such as Intralipid® have been used to reverse cardiac toxicity
induced by a number of drugs but reservations about their broad-spectrum applicability …

Well-placed local anaesthetics (LAs) can yield great clinical benefits. But systemic toxicity
related to their use can be devastating. The highly publicized case in 2004 of Mayra …

Local anesthetics are widely used clinically for perioperative analgesia to achieve comfort in
medical treatment. However, when the concentration of local anesthetics in the blood …