Recently, epigenetic alterations have been shown to be involved in the pathogenesis of
diabetes and its complications. Kidney podocytes, which are glomerular epithelial cells, are …

Regulation and action of the mineralocorticoid receptor (MR) have been the focus of
intensive research over the past 80 years. Genetic and physiological/biochemical analysis …

Diabetic nephropathy (DN) is the primary cause of end-stage renal disease, and renal
tubular cell dysfunction contributes to the pathogenesis of many kidney diseases. Our …

Chronic kidney disease (CKD) is a global health issue, affecting more than 10% of the
worldwide population. The current approach for formal diagnosis and prognostication of …

The modifications in genomic DNA methylation are involved in the regulation of normal and
pathological cellular processes. The epigenetic regulation stimulates biological plasticity as …

Type 2 diabetes (T2D) is a deficiency in how the body regulates glucose. Uncontrolled T2D
will result in chronic high blood sugar levels, eventually resulting in T2D complications …

Introduction Prior studies indicate that exposure to metals may alter DNA methylation.
Evidence also shows that global DNA methylation is associated with chronic kidney disease …

Epigenetic mechanisms are considered to contribute to diabetic nephropathy by maintaining
memory of poor glycemic control during the early stages of diabetes. However, DNA …

The number of patients with chronic kidney disease (CKD) is on the rise worldwide, and
there is urgent need for the development of effective plans against the increasing incidence …

Chronic kidney disease (CKD) was the 12th leading cause of death globally in 2017 with the
prevalence of CKD estimated at~ 9%. Early detection and intervention for CKD may improve …