[HTML][HTML] Distribution of antibiotic resistance genes in the environment

M Zhuang, Y Achmon, Y Cao, X Liang, L Chen… - Environmental …, 2021 - Elsevier
The prevalence of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs)
in the microbiome is a major public health concern globally. Many habitats in the …

[HTML][HTML] Reconstructing organisms in silico: genome-scale models and their emerging applications

X Fang, CJ Lloyd, BO Palsson - Nature Reviews Microbiology, 2020 - nature.com
Escherichia coli is considered to be the best-known microorganism given the large number
of published studies detailing its genes, its genome and the biochemical functions of its …

Metabolic interaction models recapitulate leaf microbiota ecology

M Schäfer, AR Pacheco, R Künzler, M Bortfeld-Miller… - Science, 2023 - science.org
Resource allocation affects the structure of microbiomes, including those associated with
living hosts. Understanding the degree to which this dependency determines interspecies …

Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics

X Tan, JH Letendre, JJ Collins, WW Wong - Cell, 2021 - cell.com
Synthetic biology is a design-driven discipline centered on engineering novel biological
functions through the discovery, characterization, and repurposing of molecular parts …

Genome-scale metabolic modeling enables in-depth understanding of big data

A Passi, JD Tibocha-Bonilla, M Kumar, D Tec-Campos… - Metabolites, 2021 - mdpi.com
Genome-scale metabolic models (GEMs) enable the mathematical simulation of the
metabolism of archaea, bacteria, and eukaryotic organisms. GEMs quantitatively define a …

Gapseq: informed prediction of bacterial metabolic pathways and reconstruction of accurate metabolic models

J Zimmermann, C Kaleta, S Waschina - Genome biology, 2021 - Springer
Genome-scale metabolic models of microorganisms are powerful frameworks to predict
phenotypes from an organism's genotype. While manual reconstructions are laborious …

Predictions of rhizosphere microbiome dynamics with a genome-informed and trait-based energy budget model

GL Marschmann, J Tang, K Zhalnina, U Karaoz… - Nature …, 2024 - nature.com
Soil microbiomes are highly diverse, and to improve their representation in biogeochemical
models, microbial genome data can be leveraged to infer key functional traits. By integrating …

Ecological dynamics of the gut microbiome in response to dietary fiber

H Liu, C Liao, L Wu, J Tang, J Chen, C Lei… - The ISME …, 2022 - academic.oup.com
Dietary fibers are generally thought to benefit intestinal health. Their impacts on the
composition and metabolic function of the gut microbiome, however, vary greatly across …

Quantitative principles of microbial metabolism shared across scales

D Sher, D Segrè, MJ Follows - Nature Microbiology, 2024 - nature.com
Metabolism is the complex network of chemical reactions occurring within every cell and
organism, maintaining life, mediating ecosystem processes and affecting Earth's climate …

Nitrogen recovery by a halophilic ammonium-assimilating microbiome: a new strategy for saline wastewater treatment

M Zhang, F Han, Y Li, Z Liu, H Chen, Z Li, Q Li, W Zhou - Water Research, 2021 - Elsevier
Wastewater with high salinity is one of the major challenges for conventional wastewater
treatment. Although nitrogen management is vital for wastewater treatment, efficient …