Backyard zoonoses: The roles of companion animals and peri-domestic wildlife
A Gamble, XA Olarte-Castillo… - Science Translational …, 2023 - science.org
The spillover of human infectious diseases from animal reservoirs is now well appreciated.
However, societal and climate-related changes are affecting the dynamics of such …
However, societal and climate-related changes are affecting the dynamics of such …
[HTML][HTML] Primate hemorrhagic fever-causing arteriviruses are poised for spillover to humans
CJ Warren, S Yu, DK Peters, A Barbachano-Guerrero… - Cell, 2022 - cell.com
Simian arteriviruses are endemic in some African primates and can cause fatal hemorrhagic
fevers when they cross into primate hosts of new species. We find that CD163 acts as an …
fevers when they cross into primate hosts of new species. We find that CD163 acts as an …
New SHIVs and improved design strategy for modeling HIV-1 transmission, immunopathogenesis, prevention, and cure
Previously, we showed that substitution of HIV-1 envelope (Env) residue 375-Ser by bulky
aromatic residues enhances binding to rhesus CD4 and enables primary HIV-1 Envs to …
aromatic residues enhances binding to rhesus CD4 and enables primary HIV-1 Envs to …
[HTML][HTML] Infection pressure in apes has driven selection for CD4 alleles that resist lentivirus (HIV/SIV) infection
CJ Warren, A Barbachano-Guerrero, VL Bauer… - eLife, 2024 - elifesciences.org
Simian immunodeficiency viruses (SIVs) comprise a large group of primate lentiviruses that
endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir …
endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir …
[HTML][HTML] Minimally Modified HIV-1 Infection of Macaques: Development, Utility, and Limitations of Current Models
Nonhuman primate (NHP) studies that utilize simian immunodeficiency virus (SIV) to model
human immunodeficiency virus (HIV-1) infection have proven to be powerful, highly …
human immunodeficiency virus (HIV-1) infection have proven to be powerful, highly …
[HTML][HTML] Stronger binding affinities of gp120/CD4 in Catarrhini provide insights into HIV/host interactions
Abstract Human immunodeficiency virus-1 (HIV-1) exploits the viral gp120 protein and host
CD4/CCR5 receptors for the pandemic infection to humans. The host co-receptors of not …
CD4/CCR5 receptors for the pandemic infection to humans. The host co-receptors of not …
Conformation of HIV-1 Envelope governs rhesus CD4 usage and simian-human immunodeficiency virus replication
Infection of rhesus macaques with simian-human immunodeficiency viruses (SHIVs) is the
preferred model system for vaccine development because SHIVs encode human …
preferred model system for vaccine development because SHIVs encode human …
[HTML][HTML] Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses
CJ Warren, A Barbachano-Guerrero, VL Bauer… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Simian immunodeficiency viruses (SIVs) comprise a large group of primate lentiviruses that
endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir …
endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir …
Identification of HIV-1 envelope mutations that enhance entry using macaque CD4 and CCR5
Although Rhesus macaques are an important animal model for HIV-1 vaccine development
research, most transmitted HIV-1 strains replicate poorly in macaque cells. A major genetic …
research, most transmitted HIV-1 strains replicate poorly in macaque cells. A major genetic …
Heterogeneities in infection outcomes across species: sex and tissue differences in virus susceptibility
KE Roberts, B Longdon - Peer community journal, 2023 - peercommunityjournal.org
Species vary in their susceptibility to pathogens, and this can alter the ability of a pathogen
to infect a novel host. However, many factors can generate heterogeneity in infection …
to infect a novel host. However, many factors can generate heterogeneity in infection …