Bench to bedside—new insights into the pathogenesis of necrotizing enterocolitis
Necrotizing enterocolitis (NEC) is the leading cause of death and disability from
gastrointestinal disease in premature infants. Recent discoveries have shed light on a …
gastrointestinal disease in premature infants. Recent discoveries have shed light on a …
Necrotizing enterocolitis: new insights into pathogenesis and mechanisms
Necrotizing enterocolitis (NEC) is the most frequent and lethal disease of the gastrointestinal
tract of preterm infants. At present, NEC is thought to develop in the premature host in the …
tract of preterm infants. At present, NEC is thought to develop in the premature host in the …
Exosome-derived microRNAs of human milk and their effects on infant health and development
BC Melnik, W Stremmel, R Weiskirchen, SM John… - Biomolecules, 2021 - mdpi.com
Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …
development. Milk provides a wide spectrum of mammary epithelial cell-derived …
Platelet-derived HMGB1 is a critical mediator of thrombosis
Thrombosis and inflammation are intricately linked in several major clinical disorders,
including disseminated intravascular coagulation and acute ischemic events. The damage …
including disseminated intravascular coagulation and acute ischemic events. The damage …
Necrotizing enterocolitis: It's not all in the gut
AL Meister, KK Doheny… - Experimental biology and …, 2020 - journals.sagepub.com
Necrotizing enterocolitis is the leading cause of death due to gastrointestinal disease in
preterm neonates, affecting 5–12% of neonates born at a very-low birth weight. Necrotizing …
preterm neonates, affecting 5–12% of neonates born at a very-low birth weight. Necrotizing …
The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 …
Background Necrotizing enterocolitis (NEC) develops through exaggerated toll-like receptor
4 (TLR4) signaling in the intestinal epithelium. Breast milk is rich in non-digestible …
4 (TLR4) signaling in the intestinal epithelium. Breast milk is rich in non-digestible …
A review of the immunomodulating components of maternal breast milk and protection against necrotizing enterocolitis
Breast milk contains immunomodulating components that are beneficial to newborns during
maturation of their immune system. Human breast milk composition is influenced by an …
maturation of their immune system. Human breast milk composition is influenced by an …
Toll-like receptor 4–mediated lymphocyte influx induces neonatal necrotizing enterocolitis
The nature and role of the intestinal leukocytes in necrotizing enterocolitis (NEC), a severe
disease affecting premature infants, remain unknown. We now show that the intestine in …
disease affecting premature infants, remain unknown. We now show that the intestine in …
Curcumin and intestinal inflammatory diseases: molecular mechanisms of protection
K Burge, A Gunasekaran, J Eckert… - International journal of …, 2019 - mdpi.com
Intestinal inflammatory diseases, such as Crohn's disease, ulcerative colitis, and necrotizing
enterocolitis, are becoming increasingly prevalent. While knowledge of the pathogenesis of …
enterocolitis, are becoming increasingly prevalent. While knowledge of the pathogenesis of …
The human milk oligosaccharide 2′-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the …
Necrotising enterocolitis (NEC) is a common disease in premature infants characterised by
intestinal ischaemia and necrosis. The only effective preventative strategy against NEC is …
intestinal ischaemia and necrosis. The only effective preventative strategy against NEC is …