Since the first published examination of poly (ethylenimine)(PEI) as a gene delivery vehicle,
there has been a flurry of research aimed at this polycation and its role in gene therapy …

Liposomal drug-delivery systems have come of age in recent years, with several liposomal
drugs currently in advanced clinical trials or already on the market. It is clear from numerous …

Abstract Poly (ethylenimine)(PEI) samples of various molecular weights and pHs were used
to transfect endothelial cells to achieve levels of gene expression for comparison. PEIs with …

Gene-based therapies for cancer in clinical trials include strategies that involve
augmentation of immunotherapeutic and chemotherapeutic approaches. These strategies …

A consistent neurochemical abnormality in Parkinson's disease (PD) is degeneration of
dopaminergic neurons in substantia nigra, leading to a reduction of striatal dopamine (DA) …

1. Introduction of the chemotherapies may thus be significantly reduced. The use of
polymers in the immuno-The application of polymeric materials for stimulation and for …

Heme oxygenase (HO) has been shown to be important for attenuating the overall
production of reactive oxygen species (ROS) through its ability to degrade heme and to …

Many specialists are not familiar with both drug delivery and the molecular biology of DNA
vectors. Liposomes in Gene Delivery covers both-molecular biologists will gain a basic …

How effectively and quickly endothelial caveolae can transcytose in vivo is unknown, yet
critical for understanding their function and potential clinical utility. Here we use quantitative …

Interpolyelectrolyte complexes formed as a result of the polyion coupling reaction between
polynucleotide and polycation chains have been used for gene delivery. A general …