In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …

Protein abundance differs from a few to millions of copies per cell. Trypanosoma brucei
presents an excellent model for studies on codon bias and differential gene expression …

In nearly all eukaryotes, cellular differentiation is governed by changes in transcription, and
stabilized by chromatin and DNA modification. Gene expression control in the pathogen …

Trypanosoma brucei is the causative agent of human sleeping sickness. The parasites'
variant surface glycoprotein (VSG) enables them to evade adaptive immunity via antigenic …

Kinetoplastid parasites—trypanosomes and leishmanias—infect millions of humans and
cause economically devastating diseases of livestock, and the few existing drugs have …

Gene expression is a multi-step process that converts DNA-encoded information into
proteins, involving RNA transcription, maturation, degradation, and translation. While …

Trypanosomes regulate gene expression mainly by using posttranscriptional mechanisms.
Key factors responsible for carrying out this regulation are RNA-binding proteins, affecting …

To date, most reference genomes represent a mosaic consensus sequence in which the
homologous chromosomes are collapsed into one sequence. This approach produces …

Abstract ZC3H20 and ZC3H21 are related trypanosome proteins with two C (x) 8C (x) 5C (x)
3H zinc finger motifs. ZC3H20 is present at a low level in replicating mammalian‐infective …

African trypanosome procyclic forms multiply in the midgut of tsetse flies, and are routinely
cultured at 27° C. Heat shocks of 37° C and above result in general inhibition of translation …