Nrf2 and oxidative stress: A general overview of mechanisms and implications in human disease

V Ngo, ML Duennwald - Antioxidants, 2022 - mdpi.com
Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

Nrf2/Keap1/ARE signaling: Towards specific regulation

AV Ulasov, AA Rosenkranz, GP Georgiev, AS Sobolev - Life Sciences, 2022 - Elsevier
The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …

NRF2, a transcription factor for stress response and beyond

F He, X Ru, T Wen - International journal of molecular sciences, 2020 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

NRF2 and the Hallmarks of Cancer

MR de la Vega, E Chapman, DD Zhang - Cancer cell, 2018 - cell.com
The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

Transcriptional regulation by Nrf2

C Tonelli, IIC Chio, DA Tuveson - Antioxidants & redox signaling, 2018 - liebertpub.com
Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …

Nrf2 in cancers: A double‐edged sword

S Wu, H Lu, Y Bai - Cancer medicine, 2019 - Wiley Online Library
Abstract The Nrf2/Keap1 pathway is an important signaling cascade responsible for the
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …

NRF2: KEAPing tumors protected

R Pillai, M Hayashi, AM Zavitsanou… - Cancer Discovery, 2022 - AACR
The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2–related factor 2
(NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen …

NRF2 as a regulator of cell metabolism and inflammation in cancer

F He, L Antonucci, M Karin - Carcinogenesis, 2020 - academic.oup.com
Nuclear factor erythroid 2‐related factor 2 (NRF2) is a master transcriptional regulator of
genes whose products defend our cells for toxic and oxidative insults. Although NRF2 …

Canonical and non-canonical mechanisms of Nrf2 activation

CA Silva-Islas, PD Maldonado - Pharmacological research, 2018 - Elsevier
Abstract Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that
regulates the expression of genes involved in the metabolism, immune response, cellular …

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

JD Hayes, AT Dinkova-Kostova - Trends in biochemical sciences, 2014 - cell.com
Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, also called Nfe2l2) is a transcription
factor that regulates the cellular redox status. Nrf2 is controlled through a complex …