Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Blood‐based biomarkers for Alzheimer's disease

A Leuzy, N Mattsson‐Carlgren, S Palmqvist… - EMBO molecular …, 2022 - embopress.org
Neurodegenerative disorders such as Alzheimer's disease (AD) represent a mounting public
health challenge. As these diseases are difficult to diagnose clinically, biomarkers of …

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease

DP Wightman, IE Jansen, JE Savage, AA Shadrin… - Nature …, 2021 - nature.com
Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …

The epidemiology of Alzheimer's disease modifiable risk factors and prevention

XX Zhang, Y Tian, ZT Wang, YH Ma, L Tan… - The journal of prevention …, 2021 - Springer
Mild Alzheimer's disease is the leading cause of dementia, accounting for 50–70% of cases.
Alzheimer's disease is an irreversible neurodegenerative disease, which affects daily life …

New insights into atypical Alzheimer's disease in the era of biomarkers

J Graff-Radford, KXX Yong, LG Apostolova… - The Lancet …, 2021 - thelancet.com
Most patients with Alzheimer's disease present with amnestic problems; however, a
substantial proportion, over-represented in young-onset cases, have atypical phenotypes …

Advances in the development of new biomarkers for Alzheimer's disease

TO Klyucherev, P Olszewski, AA Shalimova… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …

Aging, cellular senescence, and Alzheimer's disease

RM Liu - International journal of molecular sciences, 2022 - mdpi.com
Aging is the greatest risk factor for late-onset Alzheimer's disease (LOAD), which accounts
for> 95% of Alzheimer's disease (AD) cases. The mechanism underlying the aging-related …

The characterisation of subjective cognitive decline

F Jessen, RE Amariglio, RF Buckley… - The Lancet …, 2020 - thelancet.com
A growing awareness about brain health and Alzheimer's disease in the general population
is leading to an increasing number of cognitively unimpaired individuals, who are concerned …

Education and cognitive functioning across the life span

M Lövdén, L Fratiglioni, MM Glymour… - … science in the …, 2020 - journals.sagepub.com
Cognitive abilities are important predictors of educational and occupational performance,
socioeconomic attainment, health, and longevity. Declines in cognitive abilities are linked to …

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

DA Butterfield, B Halliwell - Nature Reviews Neuroscience, 2019 - nature.com
Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …