Lassa fever—the road ahead
RF Garry - Nature Reviews Microbiology, 2023 - nature.com
Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …
[HTML][HTML] Ribavirin for the treatment of Lassa fever: A systematic review and meta-analysis
KA Eberhardt, J Mischlinger, S Jordan, M Groger… - International Journal of …, 2019 - Elsevier
Objectives Lassa fever (LF) causes annual outbreaks in endemic regions with high mortality
of symptomatic patients. Ribavirin is recommended as standard treatment for LF in national …
of symptomatic patients. Ribavirin is recommended as standard treatment for LF in national …
Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak
The 2018 Nigerian Lassa fever season saw the largest ever recorded upsurge of cases,
raising concerns over the emergence of a strain with increased transmission rate. To …
raising concerns over the emergence of a strain with increased transmission rate. To …
Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time
Recent outbreaks of viral hemorrhagic fevers (VHFs), including Ebola virus disease (EVD)
and Lassa fever (LF), highlight the urgent need for sensitive, deployable tests to diagnose …
and Lassa fever (LF), highlight the urgent need for sensitive, deployable tests to diagnose …
Structural basis for antibody-mediated neutralization of Lassa virus
KM Hastie, MA Zandonatti, LM Kleinfelter, ML Heinrich… - Science, 2017 - science.org
The arenavirus Lassa causes severe hemorrhagic fever and a significant disease burden in
West Africa every year. The glycoprotein, GPC, is the sole antigen expressed on the viral …
West Africa every year. The glycoprotein, GPC, is the sole antigen expressed on the viral …
New hosts of the Lassa virus
Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand
people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys …
people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys …
Arbidol and other low-molecular-weight drugs that inhibit Lassa and Ebola viruses
CE Hulseberg, L Fénéant… - Journal of …, 2019 - Am Soc Microbiol
Antiviral therapies that impede virus entry are attractive because they act on the first phase
of the infectious cycle. Drugs that target pathways common to multiple viruses are …
of the infectious cycle. Drugs that target pathways common to multiple viruses are …
Clinical and laboratory predictors of Lassa fever outcome in a dedicated treatment facility in Nigeria: a retrospective, observational cohort study
P Okokhere, A Colubri, C Azubike… - The Lancet Infectious …, 2018 - thelancet.com
Background Lassa fever is a viral haemorrhagic disease endemic to west Africa. No large-
scale studies exist from Nigeria, where the Lassa virus (LASV) is most diverse. LASV …
scale studies exist from Nigeria, where the Lassa virus (LASV) is most diverse. LASV …
Geographical drivers and climate-linked dynamics of Lassa fever in Nigeria
DW Redding, R Gibb, CC Dan-Nwafor, EA Ilori… - Nature …, 2021 - nature.com
Lassa fever is a longstanding public health concern in West Africa. Recent molecular studies
have confirmed the fundamental role of the rodent host (Mastomys natalensis) in driving …
have confirmed the fundamental role of the rodent host (Mastomys natalensis) in driving …
Lassa fever: epidemiology, clinical features, diagnosis, management and prevention
Lassa fever, is an acute zoonotic disease of humans that is mainly endemic to West African
countries of Guinea, Liberia, Nigeria, and Sierra Leone. 1–3 Other countries such as Mali …
countries of Guinea, Liberia, Nigeria, and Sierra Leone. 1–3 Other countries such as Mali …