Low‐dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics

G Yang, W Li, H Jiang, X Liang, Y Zhao… - … journal of cancer, 2016 - Wiley Online Library
It has been generally accepted that both natural and man‐made sources of ionizing
radiation contribute to human exposure and consequently pose a possible risk to human …

Recurrent malignant gliomas

JP Kirkpatrick, JH Sampson - Seminars in radiation oncology, 2014 - Elsevier
In almost all patients, malignant glioma recurs following initial treatment with maximal safe
resection, conformal radiotherapy, and temozolomide. This review describes the many …

[HTML][HTML] Carcinogenesis induced by low-dose radiation

I Piotrowski, K Kulcenty, WM Suchorska… - Radiology and …, 2017 - sciendo.com
Background. Although the effects of high dose radiation on human cells and tissues are
relatively well defined, there is no consensus regarding the effects of low and very low …

[HTML][HTML] Influence of the hypersensitivity to low dose phenomenon on the tumor response to hypofractionated stereotactic body radiation therapy

E Le Reun, A Granzotto, A Pêtre, L Bodgi, G Beldjoudi… - Cancers, 2023 - mdpi.com
Simple Summary We demonstrated the possible occurrence of the hypersensitivity to low
dose (HRS) phenomenon in SBRT modality in both tumor and healthy cells. In HRS-positive …

Inter-relationship between low-dose hyper-radiosensitivity and radiation-induced bystander effects in the human T98G glioma and the epithelial HaCaT cell line

C Fernandez-Palomo, C Seymour… - Radiation …, 2016 - meridian.allenpress.com
Over the past several years, investigations in both low-dose hyper-radiosensitivity and
increased radioresistance have been a focus of radiation oncology and biology research …

Improving control of high‐grade glioma by ultra‐hyper‐fractionated radiotherapy

G Frosina - Journal of Neuroscience Research, 2022 - Wiley Online Library
Ionizing radiation is a mainstay of high‐grade glioma therapy. The current standard
radiotherapeutic schedule involves a total 60 Gy split in 2.0 Gy fractions delivered on …

Impact of time interval and dose rate on cell survival following low-dose fractionated exposures

S Terashima, Y Hosokawa, E Tsuruga… - Journal of radiation …, 2017 - academic.oup.com
Enhanced cell lethality, also known as hyper-radiosensitivity, has been reported at low
doses of radiation (≤ 0.5 Gy) in various cell lines, and is expected to be an effective cancer …

A Systematic Comparison Identifies an ATP‐Based Viability Assay as Most Suitable Read‐Out for Drug Screening in Glioma Stem‐Like Cells

A Kleijn, JJ Kloezeman, RK Balvers… - Stem cells …, 2016 - Wiley Online Library
Serum‐free culture methods for patient‐derived primary glioma cultures, selecting for glioma
stem‐like cells (GSCs), are becoming the gold standard in neurooncology research. These …

[HTML][HTML] The role and mechanism of ATM-mediated autophagy in the transition from hyper-radiosensitivity to induced radioresistance in lung cancer under low-dose …

Q Wang, Y Chen, H Chang, T Hu, J Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
Objective: This study aimed to investigate the effect of ataxia telangiectasia mutated (ATM)–
mediated autophagy on the radiosensitivity of lung cancer cells under low-dose radiation …

[HTML][HTML] Datasets of in vitro clonogenic assays showing low dose hyper-radiosensitivity and induced radioresistance

S Polgár, PN Schofield, BG Madas - Scientific Data, 2022 - nature.com
Low dose hyper-radiosensitivity and induced radioresistance are primarily observed in
surviving fractions of cell populations exposed to ionizing radiation, plotted as the function of …