Low‐dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics
G Yang, W Li, H Jiang, X Liang, Y Zhao… - … journal of cancer, 2016 - Wiley Online Library
It has been generally accepted that both natural and man‐made sources of ionizing
radiation contribute to human exposure and consequently pose a possible risk to human …
radiation contribute to human exposure and consequently pose a possible risk to human …
Recurrent malignant gliomas
JP Kirkpatrick, JH Sampson - Seminars in radiation oncology, 2014 - Elsevier
In almost all patients, malignant glioma recurs following initial treatment with maximal safe
resection, conformal radiotherapy, and temozolomide. This review describes the many …
resection, conformal radiotherapy, and temozolomide. This review describes the many …
[HTML][HTML] Carcinogenesis induced by low-dose radiation
I Piotrowski, K Kulcenty, WM Suchorska… - Radiology and …, 2017 - sciendo.com
Background. Although the effects of high dose radiation on human cells and tissues are
relatively well defined, there is no consensus regarding the effects of low and very low …
relatively well defined, there is no consensus regarding the effects of low and very low …
[HTML][HTML] Influence of the hypersensitivity to low dose phenomenon on the tumor response to hypofractionated stereotactic body radiation therapy
Simple Summary We demonstrated the possible occurrence of the hypersensitivity to low
dose (HRS) phenomenon in SBRT modality in both tumor and healthy cells. In HRS-positive …
dose (HRS) phenomenon in SBRT modality in both tumor and healthy cells. In HRS-positive …
Inter-relationship between low-dose hyper-radiosensitivity and radiation-induced bystander effects in the human T98G glioma and the epithelial HaCaT cell line
C Fernandez-Palomo, C Seymour… - Radiation …, 2016 - meridian.allenpress.com
Over the past several years, investigations in both low-dose hyper-radiosensitivity and
increased radioresistance have been a focus of radiation oncology and biology research …
increased radioresistance have been a focus of radiation oncology and biology research …
Improving control of high‐grade glioma by ultra‐hyper‐fractionated radiotherapy
G Frosina - Journal of Neuroscience Research, 2022 - Wiley Online Library
Ionizing radiation is a mainstay of high‐grade glioma therapy. The current standard
radiotherapeutic schedule involves a total 60 Gy split in 2.0 Gy fractions delivered on …
radiotherapeutic schedule involves a total 60 Gy split in 2.0 Gy fractions delivered on …
Impact of time interval and dose rate on cell survival following low-dose fractionated exposures
S Terashima, Y Hosokawa, E Tsuruga… - Journal of radiation …, 2017 - academic.oup.com
Enhanced cell lethality, also known as hyper-radiosensitivity, has been reported at low
doses of radiation (≤ 0.5 Gy) in various cell lines, and is expected to be an effective cancer …
doses of radiation (≤ 0.5 Gy) in various cell lines, and is expected to be an effective cancer …
A Systematic Comparison Identifies an ATP‐Based Viability Assay as Most Suitable Read‐Out for Drug Screening in Glioma Stem‐Like Cells
A Kleijn, JJ Kloezeman, RK Balvers… - Stem cells …, 2016 - Wiley Online Library
Serum‐free culture methods for patient‐derived primary glioma cultures, selecting for glioma
stem‐like cells (GSCs), are becoming the gold standard in neurooncology research. These …
stem‐like cells (GSCs), are becoming the gold standard in neurooncology research. These …
[HTML][HTML] The role and mechanism of ATM-mediated autophagy in the transition from hyper-radiosensitivity to induced radioresistance in lung cancer under low-dose …
Q Wang, Y Chen, H Chang, T Hu, J Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
Objective: This study aimed to investigate the effect of ataxia telangiectasia mutated (ATM)–
mediated autophagy on the radiosensitivity of lung cancer cells under low-dose radiation …
mediated autophagy on the radiosensitivity of lung cancer cells under low-dose radiation …
[HTML][HTML] Datasets of in vitro clonogenic assays showing low dose hyper-radiosensitivity and induced radioresistance
S Polgár, PN Schofield, BG Madas - Scientific Data, 2022 - nature.com
Low dose hyper-radiosensitivity and induced radioresistance are primarily observed in
surviving fractions of cell populations exposed to ionizing radiation, plotted as the function of …
surviving fractions of cell populations exposed to ionizing radiation, plotted as the function of …