The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

Aneuploidy, an abnormal chromosome composition, is a major contributor to cancer
development and progression and an important determinant of cancer therapeutic …

Chromosomal instability (CIN) generates micronuclei—aberrant extranuclear structures that
catalyze the acquisition of complex chromosomal rearrangements present in cancer …

Aneuploidy, the presence of chromosome gains or losses, is a hallmark of cancer. Here, we
describe KaryoCreate (karyotype CRISPR-engineered aneuploidy technology), a system …

Chromosome instability (CIN) is the most common form of genome instability and is a
hallmark of cancer. CIN invariably leads to aneuploidy, a state of karyotype imbalance. Here …

Microtubule-targeted agents are commonly used for cancer treatment, though many patients
do not benefit. Microtubule-targeted drugs were assumed to elicit anticancer activity via …

Chromothripsis is a catastrophic event of chromosomal instability that involves intensive
fragmentation and rearrangements within localized chromosomal regions. However, its …

Chromosome copy number imbalances, otherwise known as aneuploidies, are a common
but poorly understood feature of cancer. Here, we describe recent advances in both …

Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of
most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost …