Identification of ethanol's (EtOH) primary molecular brain targets and determination of their
functional role is an ongoing, important quest. Pentameric ligand‐gated ion channels, that is …

The inhibitory glycine receptor is a member of the Cys-loop superfamily of ligand-gated ion
channels. It is the principal mediator of rapid synaptic inhibition in the spinal cord and …

Background Taurine has chemical structure similar to an inhibitory neurotransmitter, γ-
aminobutyric acid (GABA). Previous studies on GABA in the stomach suggest GABAergic …

Acamprosate is clinically used to treat alcoholism. However, the precise molecular
functionality of acamprosate in the central nervous system remains unclear, although it is …

Background Alcohol use disorder (AUD) increases brain stress systems while suppressing
reward system functioning. One expression of stress system recruitment is elevated …

Trifluoroacetic acid is a metabolite of the inhaled anesthetics halothane, desflurane and
isoflurane as well as a major contaminant in HPLC-purified peptides. Ligand-gated ion …

The glycine receptor (GlyR) is the predominant inhibitory neurotransmitter receptor in the
brainstem and spinal cord but is also found in higher brain regions. GlyR function is affected …

We have previously demonstrated that Slc6a13-deficient (Slc6a13−/−; KO) mice are
resistant to P. multocida infection, which might be in connection with macrophage-mediated …

The inhibitory glycine receptor (GlyR) is a principal mediator of fast synaptic inhibition in
mammalian spinal cord, brainstem, and higher brain centres. Flavonoids are secondary …

Alcoholism is subject to extensive research, but the role of changes in metabolism caused
by alcohol consumption has been poorly investigated. Zinc (Zn2+) deficiency is a common …