Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered
by inflammasomes and executed by gasdermin proteins. The main characteristics of …

The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate
immune receptor protein NLRP3, adapter protein ASC, and inflammatory protease caspase …

The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …