The emerging role of the RNA-binding protein SFPQ in neuronal function and neurodegeneration
YW Lim, D James, J Huang, M Lee - International journal of molecular …, 2020 - mdpi.com
RNA-binding proteins (RBPs) are a class of proteins known for their diverse roles in RNA
biogenesis, from regulating transcriptional processes in the nucleus to facilitating translation …
biogenesis, from regulating transcriptional processes in the nucleus to facilitating translation …
The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold
Nuclear proteins are often given a concise title that captures their function, such as
'transcription factor,''polymerase'or 'nuclear-receptor.'However, for members of the …
'transcription factor,''polymerase'or 'nuclear-receptor.'However, for members of the …
The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation
M Lee, A Sadowska, I Bekere, D Ho… - Nucleic acids …, 2015 - academic.oup.com
Abstract SFPQ,(aka PSF), is a human tumor suppressor protein that regulates many
important functions in the cell nucleus including coordination of long non-coding RNA …
important functions in the cell nucleus including coordination of long non-coding RNA …
Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation
Proteins of the Drosophila behavior/human splicing (DBHS) family include mammalian
SFPQ (PSF), NONO (p54nrb), PSPC1, and invertebrate NONA and Hrp65. DBHS proteins …
SFPQ (PSF), NONO (p54nrb), PSPC1, and invertebrate NONA and Hrp65. DBHS proteins …
G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA
The long non-coding RNA NEAT1 serves as a scaffold for the assembly of paraspeckles,
membraneless nuclear organelles involved in gene regulation. Paraspeckle assembly …
membraneless nuclear organelles involved in gene regulation. Paraspeckle assembly …
Regulation of nucleolus assembly by non-coding RNA polymerase II transcripts
M Caudron-Herger, T Pankert, K Rippe - Nucleus, 2016 - Taylor & Francis
The nucleolus is a nuclear subcompartment for tightly regulated rRNA production and
ribosome subunit biogenesis. It also acts as a cellular stress sensor and can release …
ribosome subunit biogenesis. It also acts as a cellular stress sensor and can release …
[HTML][HTML] Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates
AC Marshall, J Cummins, S Kobelke, T Zhu… - Journal of molecular …, 2023 - Elsevier
Demixing of proteins and nucleic acids into condensed liquid phases is rapidly emerging as
a ubiquitous mechanism underlying the complex spatiotemporal organisation of molecules …
a ubiquitous mechanism underlying the complex spatiotemporal organisation of molecules …
Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1
GJ Knott, YS Chong, DM Passon, X Liang… - Nucleic acids …, 2022 - academic.oup.com
The Drosophila behaviour/human splicing (DBHS) proteins are a family of RNA/DNA
binding cofactors liable for a range of cellular processes. DBHS proteins include the non …
binding cofactors liable for a range of cellular processes. DBHS proteins include the non …
Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins
J Huang, GPC Garcia, MA Perugini, AH Fox… - Journal of Biological …, 2018 - ASBMB
Members of the Drosophila behavior human splicing (DBHS) protein family are nuclear
proteins implicated in many layers of nuclear functions, including RNA biogenesis as well as …
proteins implicated in many layers of nuclear functions, including RNA biogenesis as well as …
Structural plasticity of the coiled–coil interactions in human SFPQ<? mode longmeta?>
HJ Koning, JY Lai, AC Marshall, E Stroeher… - Nucleic Acids …, 2024 - academic.oup.com
The proteins SFPQ (splicing Factor Proline/Glutamine rich) and NONO (non-POU domain-
containing octamer-binding protein) are mammalian members of the Drosophila …
containing octamer-binding protein) are mammalian members of the Drosophila …