Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Abstract Helix–loop–helix (HLH) proteins are dimeric transcription factors that control
lineage-and developmental-specific gene programs. Genes encoding for HLH proteins …

Single-cell RNA-seq makes it possible to characterize the transcriptomes of cell types across
different conditions and to identify their transcriptional signatures via differential analysis …

Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the
International Cancer Genome Consortium (ICGC), we performed whole genome and …

Coordinated regulation of alternative pre-mRNA splicing is essential for germ cell
development. However, the underlying molecular mechanism that controls alternative …

Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a
given gene, which can have distinct functions. In fact, splice isoforms can have opposing …

Abstract RNA G-quadruplexes (RG4s) are four-stranded structures known to control mRNA
translation of cancer relevant genes. RG4 formation is pervasive in vitro but not in cellulo …

Small RNAs derived from mature tRNAs, referred to as tRNA fragments or “tRFs,” are an
emerging class of regulatory RNAs with poorly understood functions. We recently identified …

Cellular identity is not driven by differences in genomic content but rather by epigenomic,
transcriptomic, and proteomic heterogeneity. Although regulation of the epigenome plays a …

The self-renewal, pluripotency and differentiation of stem cells are regulated by various
genetic and epigenetic factors. As a kind of RNA binding protein (RBP), the heterogeneous …