Despite tremendous progress in recent years, our understanding of the evolution of ageing
is still incomplete. A dominant paradigm maintains that ageing evolves due to the competing …

A rapidly growing body of literature in several organisms suggests that environmentally-
induced adaptive changes in phenotype can be transmitted across multiple generations …

Hallmarks of cancer and hallmarks of aging - PMC Back to Top Skip to main content NIH
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Why and how we age are 2 intertwined questions that have fascinated scientists for many
decades. However, attempts to answer these questions remain compartmentalized …

Current thinking in life‐history theory and the biology of ageing suggests that ageing rates,
and consequently life spans, evolve largely as a function of trade‐offs with reproduction …

Life history theory has become a prominent framework in the evolutionary social sciences,
and the concept of trade-offs, the cornerstone of life history theory in studies on non-human …

Developmental trajectories of gene expression may reverse in their direction during ageing,
a phenomenon previously linked to cellular identity loss. Our analysis of cerebral cortex …

Female reproductive health has been historically understudied and underfunded. Here, we
present the advantages of using a free-living nematode, Caenorhabditis elegans, as an …

The theory that ageing evolves because of competitive resource allocation between the
soma and the germline has been challenged by studies showing that somatic maintenance …

The regulatory pathways by which gut microbiota potentially shape host life histories remain
largely untested, however, a constellation of research suggests that gut bacteria likely have …