Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience
Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …
Homeostatic control of Drosophila neuromuscular junction function
The ability to adapt to changing internal and external conditions is a key feature of biological
systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to …
systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to …
Glial sphingosine-mediated epigenetic regulation stabilizes synaptic function in Drosophila models of Alzheimer's disease
Destabilization of neural activity caused by failures of homeostatic regulation has been
hypothesized to drive the progression of Alzheimer's Disease (AD). However, the …
hypothesized to drive the progression of Alzheimer's Disease (AD). However, the …
Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
Although mTOR signaling is known as a broad regulator of cell growth and proliferation, in
neurons it regulates synaptic transmission, which is thought to be a major mechanism …
neurons it regulates synaptic transmission, which is thought to be a major mechanism …
A glutamate receptor C-tail recruits CaMKII to suppress retrograde homeostatic signaling
Presynaptic homeostatic plasticity (PHP) adaptively enhances neurotransmitter release
following diminished postsynaptic glutamate receptor (GluR) functionality to maintain …
following diminished postsynaptic glutamate receptor (GluR) functionality to maintain …
Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride …
The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this
study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for …
study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for …
Skeletal muscle mTORC1 regulates neuromuscular junction stability
M Baraldo, A Geremia, M Pirazzini… - Journal of Cachexia …, 2020 - Wiley Online Library
Background Skeletal muscle is a plastic tissue that can adapt to different stimuli. It is well
established that Mammalian Target of Rapamycin Complex 1 (mTORC1) signalling is a key …
established that Mammalian Target of Rapamycin Complex 1 (mTORC1) signalling is a key …
Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling
At the Drosophila neuromuscular junction, inhibition of postsynaptic glutamate receptors
activates retrograde signaling that precisely increases presynaptic neurotransmitter release …
activates retrograde signaling that precisely increases presynaptic neurotransmitter release …
Development of a tissue-specific ribosome profiling approach in Drosophila enables genome-wide evaluation of translational adaptations
Recent advances in next-generation sequencing approaches have revolutionized our
understanding of transcriptional expression in diverse systems. However, measurements of …
understanding of transcriptional expression in diverse systems. However, measurements of …
Sarcopenia: tilting the balance of protein homeostasis
KT Tan, STJ Ang, SY Tsai - Proteomics, 2020 - Wiley Online Library
Sarcopenia, defined as age‐associated decline of muscle mass and function, is a risk factor
for mortality and disability, and comorbid with several chronic diseases such as type II …
for mortality and disability, and comorbid with several chronic diseases such as type II …