Atherosclerosis is one of the key problems of modern medicine, which is due to the high
prevalence of atherosclerotic cardiovascular diseases and their significant share in the …

Hematopoiesis in vertebrate embryos occurs in temporally and spatially overlapping waves
in close proximity to blood vascular endothelial cells. Initially, yolk sac hematopoiesis …

The vascular endothelium is characterized by a remarkable level of plasticity, which is the
driving force not only of physiological repair/remodeling of adult tissues but also of …

Brain tumors are typically immunosuppressive and refractory to immunotherapies for
reasons that remain poorly understood. The unbiased profiling of immune cell types in the …

The formation of new vessels requires a tight synchronization between proliferation,
differentiation, and sprouting. However, how these processes are differentially activated …

Although most studies that explore the cytotoxicity of titanium dioxide nanoparticles (nano-
TiO2) have focused on cell viability and oxidative stress, the cell cycle, a basic process of …

Hematopoietic differentiation of human pluripotent stem cells (hPSCs) requires orchestration
of dynamic cell and gene regulatory networks but often generates blood cells that lack …

The developmental origin of blood-forming hematopoietic stem cells (HSCs) is a
longstanding question. Here, our non-invasive genetic lineage tracing in mouse embryos …

During embryonic development, blood cells emerge from specialized endothelial cells,
named haemogenic endothelial cells (HECs). As HECs are rare and only transiently found …

The ability to manufacture human hematopoietic stem cells (HSCs) in the laboratory holds
enormous promise for cellular therapy of human blood diseases. Several differentiation …