Treatment of Cryptococcal meningitis: how have we got here and where are we going?

NTT Ngan, B Flower, JN Day - Drugs, 2022 - Springer
Cryptococcal meningitis is a devastating brain infection cause by encapsulated yeasts of the
Cryptococcus genus. Exposure, through inhalation, is likely universal by adulthood, but …

New approaches for cryptococcosis treatment

CC Spadari, F Wirth, LB Lopes, K Ishida - Microorganisms, 2020 - mdpi.com
Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in
patients with HIV infection. The antifungal pharmacological treatment is limited to …

Alginate nanoparticles as non-toxic delivery system for miltefosine in the treatment of candidiasis and cryptococcosis

CC Spadari, FWMS de Bastiani, LB Lopes… - International journal of …, 2019 - Taylor & Francis
Introduction and objective Previous studies indicate that miltefosine (MFS) may be an
alternative as an antifungal agent; however, it presents several adverse effects. Thus, the …

Antifungal effect of volatile organic compounds produced by Pseudomonas chlororaphis subsp. aureofaciens SPS-41 on oxidative stress and mitochondrial …

Y Zhang, T Li, M Xu, J Guo, C Zhang, Z Feng… - Pesticide Biochemistry …, 2021 - Elsevier
Ceratocystis fimbriata is the pathogen of black rot disease, which widely exists in sweet
potato producing areas all over the world. The antifungal activity of volatile organic …

Antifungal drug repurposing

JH Kim, LW Cheng, KL Chan, CC Tam, N Mahoney… - Antibiotics, 2020 - mdpi.com
Control of fungal pathogens is increasingly problematic due to the limited number of
effective drugs available for antifungal therapy. Conventional antifungal drugs could also …

Sertraline as a promising antifungal agent: inhibition of growth and biofilm of Candida auris with special focus on the mechanism of action in vitro

M Gowri, B Jayashree, J Jeyakanthan… - Journal of applied …, 2020 - academic.oup.com
Aim The aim of this present study was to investigate the antifungal mechanism of sertraline
against Candida auris (C. auris) and its effect on biofilm formation. Methods and Results …

Repositionable Compounds with Antifungal Activity against Multidrug Resistant Candida auris Identified in the Medicines for Malaria Venture's Pathogen Box

G Wall, N Herrera, JL Lopez-Ribot - Journal of Fungi, 2019 - mdpi.com
Background. Candida auris has spread rapidly around the world as a causative agent of
invasive candidiasis in health care facilities and there is an urgent need to find new options …

A Novel Antimicrobial Peptide Scyreprocin From Mud Crab Scylla paramamosain Showing Potent Antifungal and Anti-biofilm Activity

Y Yang, F Chen, HY Chen, H Peng, H Hao… - Frontiers in …, 2020 - frontiersin.org
Natural antimicrobial peptides (AMPs) are potential antibiotic alternatives. Marine
crustaceans are thought to generate more powerful and various AMPs to protect themselves …

Miltefosine as an alternative strategy in the treatment of the emerging fungus Candida auris

TL Barreto, L Rossato, ALD de Freitas, JF Meis… - International journal of …, 2020 - Elsevier
Objectives Candida auris (C. auris) is an emerging fungal species that is able to develop
multidrug resistance and outbreaks of invasive infections worldwide with high mortality rates …

Sporothrix spp. Biofilms Impact in the Zoonotic Transmission Route: Feline Claws Associated Biofilms, Itraconazole Tolerance, and Potential Repurposing for …

GMP Dos Santos, LP Borba-Santos, T Vila… - Pathogens, 2022 - mdpi.com
Sporotrichosis is the most prevalent subcutaneous mycosis globally, and it is typically
caused by direct inoculation of the soil saprophytic fungus Sporothrix spp. into the patients' …