Translation initiation by cap‐dependent ribosome recruitment: Recent insights and open questions
NE Shirokikh, T Preiss - Wiley Interdisciplinary Reviews: RNA, 2018 - Wiley Online Library
Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …
decode the messenger RNA template by cycling through translation initiation, elongation …
The Yin and Yang of YY 1 in tumor growth and suppression
LM Khachigian - International journal of cancer, 2018 - Wiley Online Library
Yin Yang‐1 (YY1) is a zinc finger protein and member of the GLI‐Kruppel family that can
activate or inactivate gene expression depending on interacting partners, promoter context …
activate or inactivate gene expression depending on interacting partners, promoter context …
MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer
Background Triple-negative breast cancer (TNBC) is a poor prognostic breast cancer with
the highest mutations and limited therapeutic choices. Cytokine networking between cancer …
the highest mutations and limited therapeutic choices. Cytokine networking between cancer …
Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells
Q Fan, L Yang, X Zhang, Y Ma, Y Li, L Dong… - Journal of Experimental …, 2018 - Springer
Background Autophagy is a dynamic physiological process that can generate energy and
nutrients for cell survival during stress. Autophagy can regulate the migration and invasive …
nutrients for cell survival during stress. Autophagy can regulate the migration and invasive …
[HTML][HTML] Redox control of cancer cell destruction
Redox regulation has been proposed to control various aspects of carcinogenesis, cancer
cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As …
cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As …
[HTML][HTML] The biological implications of Yin Yang 1 in the hallmarks of cancer
Tumorigenesis is a multistep process characterized by the acquisition of genetic and
epigenetic alterations. During the course of malignancy development, tumor cells acquire …
epigenetic alterations. During the course of malignancy development, tumor cells acquire …
Targeting transcription factor YY1 for cancer treatment: current strategies and future directions
Simple Summary Cancer is a global health problem with severe consequences. Certain
genes, known as transcription factors (TFs), are overactive in many tumors. Targeting these …
genes, known as transcription factors (TFs), are overactive in many tumors. Targeting these …
Dissecting the roles and clinical potential of YY1 in the tumor microenvironment
MN Li, JX Wei, CN Xue, XT Zhou, SP Chen… - Frontiers in …, 2023 - frontiersin.org
Yin-Yang 1 (YY1) is a member of the GLI-Kruppel family of zinc finger proteins and plays a
vital dual biological role in cancer as an oncogene or a tumor suppressor during …
vital dual biological role in cancer as an oncogene or a tumor suppressor during …
Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1
Curcumin has been demonstrated to affect the chemoresistance in cancer cells of various
origins. However, its ability to modulate lactate-induced chemoresistance remains unclear …
origins. However, its ability to modulate lactate-induced chemoresistance remains unclear …
Targeting prooxidant MnSOD effect inhibits triple-negative breast cancer (TNBC) progression and M2 macrophage functions under the oncogenic stress
Triple-negative breast cancer (TNBC) has been shown with high mitochondrial oxidative
phosphorylation and production of reactive oxygen species (ROS). MnSOD (SOD2) is a …
phosphorylation and production of reactive oxygen species (ROS). MnSOD (SOD2) is a …