The ability to react to environmental change is crucial for the survival of an organism and an
essential prerequisite is the capacity to detect and respond to aversive stimuli. The …

Acid-sensing ion channels (ASICs) are ligand-gated ion channels that are exquisitely
sensitive to extracellular protons and can sense transient as well as sustained acidification …

Acid-sensing ion channels are proton-activated, sodium-selective channels composed of
three subunits, and are members of the superfamily of epithelial sodium channels …

Acid-sensing ion channels (ASICs) have long been considered as extracellular proton (H+)-
gated cation channels, and peripheral ASIC3 channels seem to be a natural sensor of acidic …

The neural crest is an evolutionary novelty that fostered the emergence of vertebrate
anatomical innovations such as the cranium and jaws. During embryonic development …

Acid-sensing ion channels (ASICs) are H+-gated Na+ channels, which are present in most, if
not all, neurons. The typical ASIC current is transient and is elicited by a rapid drop in the …

ASIC channels are bilaterian proton-gated sodium channels belonging to the large and
functionally-diverse Deg/ENaC family that also includes peptide-and mechanically-gated …

The acid‐sensing ion channels (ASICs) and epithelial sodium channels (ENaC) are
members of a superfamily of channels that play critical roles in mechanosensation …

Acid-sensing ion channels (ASICs) are proton-gated ion channels broadly expressed in the
vertebrate nervous system, converting decreased extracellular pH into excitatory sodium …

Nociceptors, ie sensory neurons tuned to detect noxious stimuli, are found in numerous
phyla of the Animalia kingdom and are often polymodal, responding to a variety of stimuli, eg …