Over the years, alkaloids derived from indole dearomatization, such as indolenine and
indolines have been evolved as promising therapeutic agents due to their important …

The chemistry of diazo compounds has a long history. It has attracted attention because of
their various useful applications in organic synthesis. In particular, they have been used …

Indoline alkaloids constitute a large class of natural products; their diverse and complex
structures contribute to potent biological activities in a range of molecules. Designing an …

Herein we report the synthesis of pyrroloindolines via a catalytic enantioselective formal [3+
2] cycloaddition of C (3)-substituted indoles. This methodology utilizes 4-aryl-1-sulfonyl-1, 2 …

Cyclization and annulation reactions initiated by ring-opening of small rings, especially
cyclopropanes and cyclobutanes are now well-established in synthetic chemistry …

Recent advances in single-atom insertion reactions have opened up new synthetic
approaches for molecular diversification. Developing innovative strategies to directly …

The akuammiline alkaloids are a family of intricate natural products which have received
considerable attention from scientists worldwide. Despite the fact that many members of this …

The catalytic asymmetric synthesis of 3, 3-disubstituted oxindoles, a big family of privileged
scaffolds in natural products and drugs, is of current interest. Recently, the catalytic …

The first total synthesis of the akuammiline alkaloid (±)-vincorine (6) has been accomplished
in about 1% overall yield in 31 steps. A concise assembly of the core 1, 2-disubstituted 1, 2 …

The first enantioselective copper-catalyzed cyclopropanation of N-acyl indoles is described.
Using carbohydrate-based bis (oxazoline) ligands (gluco Box), the products were obtained …