The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

Exercise is the most important physiological stimulus for increased myocardial oxygen
demand. The requirement of exercising muscle for increased blood flow necessitates an …

BACKGROUND Profound reduction in antegrade epicardial coronary flow with concomitant
ischemia is seen occasionally during percutaneous coronary intervention despite the …

Slow flow of dye in epicardial coronary arteries is not an infrequent finding in patients during
routine coronary angiography. Whether this pattern of flow can be reversed by nitroglycerin …

▪ Abstract Blood flow in the microcirculation is regulated by physiological oxygen (O2)
gradients that are coupled to vasoconstriction or vasodilation, the domain of nitric oxide (NO) …

A continuous supply of oxygen is essential for the survival of multicellular organisms. The
understanding of how this supply is regulated in the microvasculature has evolved from …

Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide
dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator …

Coronary slow flow (CSF) is an angiographic phenomenon with specific epidemiologic
characteristics, associated clinical presentation, and prognosis. Although patients with CSF …

Objectives The present study aimed to assess the feasibility and clinical value of
acetylcholine (ACh) rechallenge for the detection of coexisting epicardial and microvascular …

The control of force production in vascular smooth muscle is critical to the normal regulation
of blood flow and pressure, and altered regulation is common to diseases such as …