The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

Many oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors
to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs …

Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …

Dysregulation of the B-cell leukemia/lymphoma-2 (BCL-2) family of proteins of the intrinsic
apoptotic pathway is fundamental to the pathophysiology of many hematologic …

Small molecule inhibitors that target components of the spliceosome have great potential as
tools to probe splicing mechanism and dissect splicing regulatory networks in cells. These …

Mucosal melanomas are a rare subtype of melanoma, arising in mucosal tissues, which
have a very poor prognosis due to the lack of effective targeted therapies. This study aimed …

Alternative pre-mRNA splicing (AS) provides the potential to produce diversity at RNA and
protein levels. Disruptions in the regulation of pre-mRNA splicing can lead to diseases. With …

Background Dysregulation of splicing variants (SVs) expression has recently emerged as a
novel cancer hallmark. Although the generation of aberrant SVs (eg AR-v7/sst5TMD4/etc.) is …

Alternative splicing generates a diversity of messenger RNA (mRNA) transcripts from a
single mRNA precursor and contributes to the complexity of our proteome. Splicing is …