Organelle-level precision with next-generation targeting technologies
Intracellular organelles are subsystems within a cell, whose activity and chemical
composition reflect the metabolic state of live cells. Alterations in cellular homeostasis …
composition reflect the metabolic state of live cells. Alterations in cellular homeostasis …
Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics
AH Merrill Jr - Chemical reviews, 2011 - ACS Publications
Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …
naming of sphingosine “in commemoration of the many enigmas which it presented to the …
Shiga toxins
J Bergan, ABD Lingelem, R Simm, T Skotland… - Toxicon, 2012 - Elsevier
Shiga toxins are virulence factors produced by the bacteria Shigella dysenteriae and certain
strains of Escherichia coli. There is currently no available treatment for disease caused by …
strains of Escherichia coli. There is currently no available treatment for disease caused by …
Shiga toxins as multi-functional proteins: Induction of host cellular stress responses, role in pathogenesis and therapeutic applications
Shiga toxins (Stxs) produced by Shiga toxin-producing bacteria Shigella dysenteriae
serotype 1 and select serotypes of Escherichia coli are primary virulence factors in the …
serotype 1 and select serotypes of Escherichia coli are primary virulence factors in the …
Glycolipids and lectins in endocytic uptake processes
A host of endocytic processes has been described at the plasma membrane of eukaryotic
cells. Their categorization has most commonly referenced cytosolic machinery, of which the …
cells. Their categorization has most commonly referenced cytosolic machinery, of which the …
Shiga toxin interaction with human intestinal epithelium
S Schüller - Toxins, 2011 - mdpi.com
After ingestion via contaminated food or water, enterohaemorrhagic E. coli colonises the
intestinal mucosa and produces Shiga toxins (Stx). No Stx-specific secretion system has …
intestinal mucosa and produces Shiga toxins (Stx). No Stx-specific secretion system has …
Recent advances in biomimetic nanocarrier-based photothermal therapy for cancer treatment
J Gallo, A Villasante - International Journal of Molecular Sciences, 2023 - mdpi.com
Nanomedicine presents innovative solutions for cancer treatment, including photothermal
therapy (PTT). PTT centers on the design of photoactivatable nanoparticles capable of …
therapy (PTT). PTT centers on the design of photoactivatable nanoparticles capable of …
Deciphering the importance of glycosphingolipids on cellular and molecular mechanisms associated with epithelial-to-mesenchymal transition in cancer
Every living cell is covered with a dense and complex layer of glycans on the cell surface,
which have important functions in the interaction between cells and their environment …
which have important functions in the interaction between cells and their environment …
Shiga toxins: from structure and mechanism to applications
YS Chan, TB Ng - Applied microbiology and biotechnology, 2016 - Springer
Shiga toxins are a group of type 2 ribosome-inactivating proteins (RIPs) produced in several
types of bacteria. The toxins possess an AB 5 structure, which comprises a catalytic A chain …
types of bacteria. The toxins possess an AB 5 structure, which comprises a catalytic A chain …
Structural diversities of lectins binding to the glycosphingolipid Gb3
Glycolipids are present on the surfaces of all living cells and thereby represent targets for
many protein receptors, such as lectins. Understanding the interactions between lectins and …
many protein receptors, such as lectins. Understanding the interactions between lectins and …