Mechanical and biological effects of ultrasound: a review of present knowledge

Z Izadifar, P Babyn, D Chapman - Ultrasound in medicine & biology, 2017 - Elsevier
Ultrasound is widely used for medical diagnosis and increasingly for therapeutic purposes.
An understanding of the bio-effects of sonography is important for clinicians and scientists …

Ultrasound-induced blood-brain barrier opening

EE Konofagou, YS Tunga, J Choia… - Current …, 2012 - ingentaconnect.com
Over 4 million US men and women suffer from Alzheimer's disease; 1 million from
Parkinson's disease; 350,000 from multiple sclerosis (MS); and 20,000 from amyotrophic …

Effective parameters for ultrasound-induced in vivo neurostimulation

RL King, JR Brown, WT Newsome, KB Pauly - Ultrasound in medicine & …, 2013 - Elsevier
Ultrasound-induced neurostimulation has recently gained increasing attention, but little is
known about the mechanisms by which it affects neural activity or about the range of …

In vivo transcranial cavitation threshold detection during ultrasound-induced blood–brain barrier opening in mice

YS Tung, F Vlachos, JJ Choi, T Deffieux… - Physics in Medicine …, 2010 - iopscience.iop.org
The in vivo cavitation response associated with blood–brain barrier (BBB) opening as
induced by transcranial focused ultrasound (FUS) in conjunction with microbubbles was …

[HTML][HTML] Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening

RM Jones, L Deng, K Leung, D McMahon… - Theranostics, 2018 - ncbi.nlm.nih.gov
Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening recently entered
clinical testing for targeted drug delivery to the brain. Sources of variability exist in the …

Quantitative frequency-domain passive cavitation imaging

KJ Haworth, KB Bader, KT Rich… - IEEE transactions on …, 2016 - ieeexplore.ieee.org
Passive cavitation detection has been an instrumental technique for measuring cavitation
dynamics, elucidating concomitant bioeffects, and guiding ultrasound therapies. Recently …

The mechanism of interaction between focused ultrasound and microbubbles in blood-brain barrier opening in mice

YS Tung, F Vlachos, JA Feshitan, MA Borden… - The Journal of the …, 2011 - pubs.aip.org
The activation of bubbles by an acoustic field has been shown to temporarily open the blood-
brain barrier (BBB), but the trigger cause responsible for the physiological effects involved in …

Passive spatial mapping of inertial cavitation during HIFU exposure

M Gyongy, CC Coussios - IEEE Transactions on Biomedical …, 2009 - ieeexplore.ieee.org
A novel method for mapping inertial cavitation activity during high-intensity focused
ultrasound (HIFU) exposure is presented. Inertial cavitation has been previously shown to …

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

K Hynynen, RM Jones - Physics in Medicine & Biology, 2016 - iopscience.iop.org
Focused ultrasound offers a non-invasive way of depositing acoustic energy deep into the
body, which can be harnessed for a broad spectrum of therapeutic purposes, including …

Shock-induced heating and millisecond boiling in gels and tissue due to high intensity focused ultrasound

MS Canney, VA Khokhlova, OV Bessonova… - Ultrasound in medicine …, 2010 - Elsevier
Nonlinear propagation causes high-intensity ultrasound waves to distort and generate
higher harmonics, which are more readily absorbed and converted to heat than the …