OF THE WORLD HEALTH ORGANIZATION CLASSIFICATION OF TUMORS OF THE HEMATOPOIETIC AND LYMPHOID TISSUES
This manuscript represents a review of lymphoblastic leukemia/lymphoma (acute
lymphoblastic leukemia/lymphoblastic lymphoma), acute leukemias of ambiguous lineage …
lymphoblastic leukemia/lymphoblastic lymphoma), acute leukemias of ambiguous lineage …
Oncogenic kinase signalling
P Blume-Jensen, T Hunter - Nature, 2001 - nature.com
Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction
pathways mediating development and multicellular communication in metazoans. Their …
pathways mediating development and multicellular communication in metazoans. Their …
[HTML][HTML] H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
The mechanisms underlying gene repression and silencers are poorly understood. Here we
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
EJ Baxter, LM Scott, PJ Campbell, C East… - The Lancet, 2005 - thelancet.com
Background Human myeloproliferative disorders form a range of clonal haematological
malignant diseases, the main members of which are polycythaemia vera, essential …
malignant diseases, the main members of which are polycythaemia vera, essential …
[HTML][HTML] Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and …
Eurycoma longifolia Jack (known as tongkat ali), a popular traditional herbal medicine, is a
flowering plant of the family Simaroubaceae, native to Indonesia, Malaysia, Vietnam and …
flowering plant of the family Simaroubaceae, native to Indonesia, Malaysia, Vietnam and …
JNK signalling in cancer: in need of new, smarter therapeutic targets
The JNKs are master protein kinases that regulate many physiological processes, including
inflammatory responses, morphogenesis, cell proliferation, differentiation, survival and …
inflammatory responses, morphogenesis, cell proliferation, differentiation, survival and …
The impact of translocations and gene fusions on cancer causation
F Mitelman, B Johansson, F Mertens - Nature Reviews Cancer, 2007 - nature.com
Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …
[HTML][HTML] Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
E Weisberg, PW Manley, W Breitenstein, J Brüggen… - Cancer cell, 2005 - cell.com
Summary The Bcr-Abl tyrosine kinase oncogene causes chronic myelogenous leukemia
(CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) …
(CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) …
[HTML][HTML] Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
AS Corbin, A Agarwal, M Loriaux… - The Journal of …, 2011 - Am Soc Clin Investig
Imatinib therapy, which targets the oncogene product BCR-ABL, has transformed chronic
myeloid leukemia (CML) from a life-threatening disease into a chronic condition. Most …
myeloid leukemia (CML) from a life-threatening disease into a chronic condition. Most …
Mechanisms of BCR–ABL in the pathogenesis of chronic myelogenous leukaemia
R Ren - Nature Reviews Cancer, 2005 - nature.com
Imatinib, a potent inhibitor of the oncogenic tyrosine kinase BCR–ABL, has shown
remarkable clinical activity in patients with chronic myelogenous leukaemia (CML) …
remarkable clinical activity in patients with chronic myelogenous leukaemia (CML) …