The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …

Autoimmunity refers to the phenomenon that the body's immune system produces antibodies
or sensitized lymphocytes to its own tissues to cause an immune response. Immune …

Iron is necessary for various critical biological processes, but iron overload is also
dangerous since labile iron is redox-active and toxic. We found that low serum iron and …

Deficiency of decidual NK (dNK) cell number and function has been widely regarded as an
important cause of spontaneous abortion. However, the metabolic mechanism underlying …

BACKGROUND With increasing significance of developmental programming effects
associated with placental dysfunction, more investigations are devoted to improving the …

Patients with recurrent pregnancy loss (RPL) account for approximately 1%-5% of women
aiming to achieve childbirth. Although studies have shown that RPL is associated with …

Background Recurrent spontaneous abortion (RSA) is a challenging condition that affects
the health of women both physically and mentally, but its pathogenesis and treatment have …

Successful conception requires the synchrony of multiple systems and organs.
Dysregulation of stromal cell–immune cell interactions has been proposed to be associated …

Single-cell RNA-sequencing (scRNA-seq) allows the characterization of cellular
composition and interactions in complex tissues. An essential prerequisite for scRNA-seq is …

Pregnancy success requires constant dialogue between the mother and developing
conceptus. Such crosstalk is facilitated through complex interactions between maternal and …