A dense and diverse array of glycans on glycoproteins and glycolipids decorate all cell
surfaces. In vertebrates, many of these carry sialic acid, in a variety of linkages and glycan …

The structure of a sialoglycan can be translated into to a biological response when it binds to
a specific endogenous lectin. Among endogenous sialic acid-binding lectins in humans are …

Siglecs (sialic acid-binding immunoglobulin-like lectins) are a family of vertebrate glycan-
binding cell-surface proteins. The majority mediate cellular inhibitory activity once engaged …

The term “allergic diseases” encompasses several common, IgE-mediated conditions that
range from being annoying to those that are life-threatening. Available treatments include …

Most human Siglecs (sialic acid binding immunoglobulin-like lectins) are expressed on the
surfaces of overlapping subsets of immune cells, and most carry immunoreceptor tyrosine …

Human sialic acid-binding immunoglobulin-like lectins (Siglecs) are expressed on subsets
of immune cells. Siglec-8 is an immune inhibitory Siglec on eosinophils and mast cells …

Mast cells (MCs) contribute prominently to all allergic diseases, yet are still poorly
understood owing to their exclusive residence in tissues. Recently, the use of RNA …

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disorder
whose complex immunopathogenesis has yet to be fully elucidated. Endotype-2 CRSwNP is …

Background Cystic fibrosis (CF) is the most common genetic disorder in the Caucasian
population. Despite remarkable improvements in morbidity and mortality during the last …

Glycan-lectin recognition underlies a myriad of cellular functions. Siglecs (Sialic acid-
binding immunoglobulin-like lectins) are expressed on unique subsets of white blood cells …