Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

T cell anergy is a tolerance mechanism in which the lymphocyte is intrinsically functionally
inactivated following an antigen encounter, but remains alive for an extended period of time …

Inducing antigen-specific tolerance during an established immune response typically
requires non-specific immunosuppressive signalling molecules. Hence, standard treatments …

We examined the regulation of virus-specific CD8 T cell responses during chronic
lymphocytic choriomeningitis virus (LCMV) infection of mice. Our study shows that within the …

The role of anergy, an acquired state of T cell functional unresponsiveness, in natural
peripheral tolerance remains unclear. In this study, we found that anergy was selectively …

The mammalian immune system discriminates between modes of cell death; necrosis often
results in inflammation and adaptive immunity, whereas apoptosis tends to be anti …

It is thought that immunity depends on naïve CD4 T cells that proliferate in response to
microbial antigens,,,, differentiate into memory cells that produce anti-microbial …

The remarkable capacity of the mammalian immune system to coordinate deadly attacks
against numerous invading pathogens, yet turn a blind eye to self-tissues continues to …

Abstract The OX-40 receptor (OX-40R), a member of the TNFR family, is primarily expressed
on activated CD4+ T lymphocytes. Engagement of the OX-40R, with either OX-40 ligand (OX …

Physical detection of antigen-specific CD4 T cells has revealed features of the in vivo
immune response that were not appreciated from in vitro studies. In vivo, antigen is initially …