Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung Cells

J Papies, J Emanuel, N Heinemann, Ž Kulić… - Frontiers in …, 2021 - frontiersin.org
Treatment options for COVID-19 are currently limited. Drugs reducing both viral loads and
SARS-CoV-2-induced inflammatory responses would be ideal candidates for COVID-19 …

In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron …

J Emanuel, J Papies, C Galander, JM Adler… - Frontiers in …, 2023 - frontiersin.org
The occurrence of immune-evasive SARS-CoV-2 strains emphasizes the importance to
search for broad-acting antiviral compounds. Our previous in vitro study showed that …

Recovery of infective virus particles in ion-exchange and hydrophobic interaction monolith chromatography is influenced by particle charge and total-to-infective …

D Sviben, D Forcic, J Ivancic-Jelecki, B Halassy… - … of Chromatography B, 2017 - Elsevier
Viral particles are used in medical applications as vaccines or gene therapy vectors. In order
to obtain product of high purity, potency and safety for medical use purification of virus …

Antigenic differences between vaccine and circulating wild-type mumps viruses decreases neutralization capacity of vaccine-induced antibodies

M Šantak, M LANG-BALIJA, J Ivancic-Jelecki… - Epidemiology & …, 2013 - cambridge.org
A recent resurgence of mumps in doubly vaccinated cohorts has been observed, identifying
genotype G as the current predominant genotype. In this study, the neutralization efficacy of …

Dry powder measles vaccine: particle deposition, virus replication, and immune response in cotton rats following inhalation

KO Kisich, MP Higgins, I Park, SP Cape, L Lindsay… - Vaccine, 2011 - Elsevier
A stable and high potency dry powder measles vaccine with a particle size distribution
suitable for inhalation was manufactured by CO2-Assisted Nebulization with a Bubble …

[HTML][HTML] Accumulation of defective interfering viral particles in only a few passages in Vero cells attenuates mumps virus neurovirulence

M Šantak, M Markušić, ML Balija, SK Kopač, R Jug… - Microbes and …, 2015 - Elsevier
Immunization programs have implemented live attenuated mumps vaccines which reduced
mumps incidence≥ 97%. Some of the vaccine strains were abandoned due to unwanted …

Stability, biophysical properties and effect of ultracentrifugation and diafiltration on measles virus and mumps virus

D Sviben, D Forčić, T Kurtović, B Halassy, M Brgles - Archives of virology, 2016 - Springer
Measles virus and mumps virus (MeV and MuV) are enveloped RNA viruses used for
production of live attenuated vaccines for prophylaxis of measles and mumps disease …

Stability of Minimum Essential Medium functionality despite l-glutamine decomposition

M Jagušić, D Forčić, M Brgles, L Kutle, M Šantak… - Cytotechnology, 2016 - Springer
Abstract l-Glutamine (l-Gln) instability in liquid media is a well-known fact. Also, negative
effect of ammonia, one of the l-Gln degradation products, on viability of many cell cultures …

Nonspecific native elution of proteins and mumps virus in immunoaffinity chromatography

M Brgles, D Sviben, D Forčić, B Halassy - Journal of chromatography A, 2016 - Elsevier
Immunoaffinity chromatography, based on the antigen-antibody recognition, enables
specific purification of any antigen (protein, virus) by its antibody. The problem with …

Identification of conformational neutralization sites on the fusion protein of mumps virus

M Šantak, C Örvell, TK Gulija - Journal of General …, 2015 - microbiologyresearch.org
In spite of the success of the mumps vaccination, recent mumps outbreaks have been
reported even among individuals with a history of mumps vaccination. For a better …