Next-generation approaches to understand and combat the antibiotic resistome

TS Crofts, AJ Gasparrini, G Dantas - Nature Reviews Microbiology, 2017 - nature.com
Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …

Captivity and animal microbiomes: potential roles of microbiota for influencing animal conservation

JW Dallas, RW Warne - Microbial ecology, 2023 - Springer
During the ongoing biodiversity crisis, captive conservation and breeding programs offer a
refuge for species to persist and provide source populations for reintroduction efforts …

Impact of sequencing depth on the characterization of the microbiome and resistome

R Zaheer, N Noyes, R Ortega Polo, SR Cook… - Scientific reports, 2018 - nature.com
Developments in high-throughput next generation sequencing (NGS) technology have
rapidly advanced the understanding of overall microbial ecology as well as occurrence and …

The gut microbiome as a reservoir for antimicrobial resistance

WE Anthony, CAD Burnham, G Dantas… - The Journal of …, 2021 - academic.oup.com
This review will consider the gut as a reservoir for antimicrobial resistance, colonization
resistance, and how disruption of the microbiome can lead to colonization by pathogenic …

Thinking outside the box—novel antibacterials to tackle the resistance crisis

M Lakemeyer, W Zhao, FA Mandl… - Angewandte Chemie …, 2018 - Wiley Online Library
The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …

Antibiotic resistant bacteria in municipal wastes: is there reason for concern?

IL Pepper, JP Brooks, CP Gerba - Environmental science & …, 2018 - ACS Publications
Recently, there has been increased concern about the presence of antibiotic resistant
bacteria (ARB) and antibiotic resistant genes (ARG), in treated domestic wastewaters …

Antibiotic resistance in recreational waters: state of the science

SP Nappier, K Liguori, AM Ichida, JR Stewart… - International journal of …, 2020 - mdpi.com
Ambient recreational waters can act as both recipients and natural reservoirs for
antimicrobial resistant (AMR) bacteria and antimicrobial resistant genes (ARGs), where they …

Multiscale evolutionary dynamics of host-associated microbiomes

A Ferreiro, N Crook, AJ Gasparrini, G Dantas - Cell, 2018 - cell.com
The composite members of the microbiota face a range of selective pressures and must
adapt to persist in the host. We highlight recent work characterizing the evolution and …

Halocins, natural antimicrobials of Archaea: Exotic or special or both?

V Kumar, B Singh, MJ van Belkum, DB Diep… - Biotechnology …, 2021 - Elsevier
Haloarchaea are adapted to survive under extreme saline conditions by accumulating
osmolytes and salts to counteract the high osmotic pressure in their habitats. As a …

Diversity, ecology, and prevalence of antimicrobials in nature

MM Mullis, IM Rambo, BJ Baker, BK Reese - Frontiers in microbiology, 2019 - frontiersin.org
Microorganisms possess a variety of survival mechanisms, including the production of
antimicrobials that function to kill and/or inhibit the growth of competing microorganisms …