Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

Eutectics are a long known class of multi-component solids with important and useful
applications in daily life. In comparison to other multi-component crystalline solids, such as …

Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient
are the major constraints during the development of new product. Various approaches have …

Introduction: To overcome potential problems with solid-state APIs, such as polymorphism,
solubility and bioavailability, pure liquid salt (ionic liquid) forms of active pharmaceutical …

Citric acid, a tricarboxylic acid, has found wide application in the chemical and
pharmaceutical industry due to its biocompatibility, versatility, and green, environmentally …

Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …

Amphotericin B and itraconazole were used to demonstrate that ionic liquids can be
designed or chosen to provide tunable hydrophilicity in one ion and lipophilicity in the other …

Salification of new drug substances in order to improve physico-chemical or solid-state
properties (eg dissolution rate or solubility, appropriate workup process, storage for further …

Myricetin shows low oral bioavailability (< 10%) in rats due to poor aqueous solubility,
although it has demonstrated various pharmacological activities such as those related to …