Mitochondria play a central role in maintaining cells alive, but are also important mediators
of cell death. The main event in mitochondrial signalling and control of apoptosis is the …

Fas (also called CD95 or APO-1), a member of a subgroup of the tumour necrosis factor
receptor superfamily that contain an intracellular death domain, can initiate apoptosis …

The localization and control of Bcl-2 proteins on mitochondria is essential for the intrinsic
pathway of apoptosis. Anti-apoptotic Bcl-2 proteins reside on the outer mitochondrial …

The endoplasmic reticulum (ER) and mitochondria form contacts that support
communication between these two organelles, including synthesis and transfer of lipids, and …

Individual BCL2 family members couple apoptosis regulation and cell cycle control in
unique ways. Antiapoptotic BCL2 and BCL-x L are antiproliferative by facilitating G0. BAX is …

The relatively common occurrence of sequences within proteins that match the consensus
substrate specificity of caspases in intracellular proteins suggests a multitude of substrates …

Programmed cell death (PCD) is essential for normal development and maintenance of
tissue homeostasis in multicellular organisms. While it is now evident that PCD can take …

GMX1777 is a prodrug of the small molecule GMX1778, currently in phase I clinical trials for
the treatment of cancer. We describe findings indicating that GMX1778 is a potent and …

The BH3-only protein Bid is known as a critical mediator of the mitochondrial pathway of
apoptosis following death receptor activation. However, since full-length Bid possesses …

Cellular reactive oxygen species (ROS) are tightly regulated to prevent tissue damage. ROS
also help to monitor different cell fates, suggesting that a 'ROS rheostat'exists in cells. It is …