The thymus is an organ that is critically important to the immune system, which serves as the
body's defense mechanism, providing surveillance and protection against diverse …

The chemokine superfamily consists of a large number of ligands and receptors. At first
glance, this family appears redundant and their ligand-receptor relationships promiscuous …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

T cell development in the mouse thymus has been studied extensively, but less is known
regarding T cell development in the human thymus. We used a combination of single-cell …

As potent antigen-presenting cells, dendritic cells (DCs) comprise the most heterogeneous
cell population with significant cellular phenotypic and functional plasticity. They form a …

The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …

T cells are the key mediators in cell-mediated immunity. Their development and maturation
involve a complex variety of interactions with nonlymphoid cell products and receptors …

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of
migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of …

Central tolerance can be mediated by peripheral dendritic cells (DCs) that transport
innocuous antigens (Ags) to the thymus for presentation to developing T cells, but the …

During postnatal life, thymopoiesis depends on the continuous colonization of the thymus by
bone-marrow-derived hematopoietic progenitors that migrate through the bloodstream. The …