Progress in the Application of Drugs for the Treatment of Multiple Sclerosis

W Wei, D Ma, L Li, L Zhang - Frontiers in Pharmacology, 2021 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune and chronic inflammatory demyelinating disease
of the central nervous system (CNS), which gives rise to focal lesion in CNS and cause …

[HTML][HTML] Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis

NJ Wasko, F Nichols, RB Clark - Autoimmunity reviews, 2020 - Elsevier
The pathophysiology of autoimmune diseases such as Multiple Sclerosis (MS) involves a
complex interaction between genetic and environmental factors. Studies of monozygotic …

Leukemia inhibitory factor regulates Schwann cell proliferation and migration and affects peripheral nerve regeneration

Q Chen, Q Liu, Y Zhang, S Li, S Yi - Cell Death & Disease, 2021 - nature.com
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that stimulates neuronal
development and survival. Our previous study has demonstrated that LIF mRNA is …

Systemic TLR2 tolerance enhances central nervous system remyelination

NJ Wasko, MH Kulak, D Paul, AM Nicaise… - Journal of …, 2019 - Springer
Background Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease
characterized by both inflammatory demyelination and impaired remyelination. Studies …

Leukemia inhibitory factor: Recent advances and implications in biotechnology

V Pinho, M Fernandes, A da Costa, R Machado… - Cytokine & growth factor …, 2020 - Elsevier
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine with several functions in health and
disease ranging from inflammation to cancer. LIF is also a potential target and/or therapeutic …

From Immunity to Neurogenesis: Toll-like Receptors as Versatile Regulators in the Nervous System

DM Abarca-Merlin, JA Martínez-Durán… - International Journal of …, 2024 - mdpi.com
Toll-like receptors (TLRs) are among the main components of the innate immune system.
They can detect conserved structures in microorganisms and molecules associated with …

[HTML][HTML] Delivery of Neuroregenerative Proteins to the Brain for Treatments of Neurodegenerative Brain Diseases

ET Ebert, KM Schwinghamer, TJ Siahaan - Life, 2024 - mdpi.com
Neurodegenerative brain diseases such as Alzheimer's disease (AD), multiple sclerosis
(MS), and Parkinson's disease (PD) are difficult to treat. Unfortunately, many therapeutic …

[图书][B] The Role of TLR2 Tolerance in Remyelination Following Cuprizone-Induced Myelin Injury

NJ Wasko - 2021 - search.proquest.com
Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease
characterized by both inflammatory demyelination and impaired remyelination. Studies …