Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …

Biological information is stored by DNA and manifested by proteins. RNA serves as the
conduit: 1 The flow of information through RNA is essential for known life. By catalyzing the …

THE leucine-rich repeat is a recently characterized structural motif1 used in molecular
recognition processes as diverse as signal transduction, cell adhesion, cell development …

THE mechanisms through which synaptic vesicle membranes are reinternalized after
exocytosis remain a matter of debate1–5. Because several vesicular transport steps require …

A model is proposed of the polypeptide chain in bovine pancreatic ribonuclease based on a
2 Å electron density map involving 7,294 reflexions and data from seven heavy atom …

The structure of phosphate-free bovine ribonuclease A has been refined at 1.26-Á resolution
by a restrained least-squares procedure to a final R factor of 0.15. X-ray diffraction data were …

Publisher Summary This chapter discusses the process of isolation, chromatography,
structure, and molecular and catalytic properties of bovine pancreatic ribonuclease. At …

As a contribution to the celebration of the year 2014, declared by the United Nations to be
'The International Year of Crystallography', the FEBS Journal is dedicating this issue to …

Bovine pancreatic ribonuclease A (RNase A; EC3. 1.27. 5) has been one of the most studied
of all enzymes. 1 RNase A efficiently catalyzes the cleavage of RNÁ. 2 Early X-ray diffraction …

Diribonucleotides arise from two sources: turnover of RNA transcripts (rRNA, tRNA, mRNA,
and others) and linearization of cyclic-di-nucleotide signaling molecules. In both cases …