Implications of viral infections and oncogenesis in uterine cervical carcinoma etiology and pathogenesis

D Chu, T Liu, Y Yao - Frontiers in Microbiology, 2023 - frontiersin.org
Background Uterine Cervical Carcinoma (UCC) is the most prevalent gynecological
malignancy globally, with a rising incidence in recent years. Accumulating evidence …

A novel photoelectrochemical array platform for ultrasensitive multiplex detection and subtype identification of HPV genes

Y Sun, J Liu, X Peng, G Zhang, Y Li - Biosensors and Bioelectronics, 2023 - Elsevier
The rapid, low-cost and user-friendly methods for nucleic acid detection is urgently needed.
Here we developed a miniaturized and convenient photoelectrochemical biosensor array …

TLR9 in the human papilloma virus infections: friend or foe?

B Douzandeh-Mobarrez, A Kariminik… - Viral …, 2022 - liebertpub.com
Immune system plays dual roles during human papilloma virus (HPV) infections, from
defense against the virus to induction or stimulation of the HPV-related cancers. It appears …

Association of TLR4 and TLR9 gene polymorphisms with cervical HR-HPV infection status in Chinese Han population

C Zhang, Z Yang, P Luo, T Li, S Wang, F Sun… - BMC Infectious …, 2023 - Springer
Abstract Background Toll-like receptors (TLRs) may be involved in the natural history of
human papillomavirus (HPV) infection. In our study, we aimed to investigate the association …

Bioinformatics analysis to identify the relationship between human papillomavirus-associated cervical cancer, toll-like receptors and exomes: A genetic epidemiology …

FC Gomes, DR Galhardo, ACG Navegante, GS Santos… - Plos one, 2024 - journals.plos.org
Introduction Genetic variants may influence Toll-like receptor (TLR) signaling in the immune
response to human papillomavirus (HPV) infection and lead to cervical cancer. In this study …

Designing a Novel Multiepitope Vaccine from the Human Papilloma Virus E1 and E2 Proteins for Indonesia with Immunoinformatics and Molecular Dynamics …

Rizarullah, R Aditama, EA Giri-Rachman, R Hertadi - ACS omega, 2024 - ACS Publications
One of the deadliest malignant cancer in women globally is cervical cancer. Specifically,
cervical cancer is the second most common type of cancer in Indonesia. The main infectious …

Toll-like receptor-4 antagonist enhances the repair of ultraviolet radiation-induced DNA damage and augments anti-tumor immune responses in mice

MA Sherwani, A Abdelgawad, M Chung, S Ibrahim… - Cancers, 2021 - mdpi.com
Simple Summary Ultraviolet B (UVB) radiation is largely responsible for the development of
skin cancer. When UVB-induced DNA damage in cells is not repaired, it can lead to the …

Comparing the distribution of common human papillomavirus genotypes among the population of Fars province in southwest Iran with the genotypes included in the …

M Kalani, F Mirzaei, H Keyghobadi… - Molecular Biology …, 2024 - Springer
Background Given the strong association between high-risk HPV genotypes, such as HPV
16 and 18, and cervical cancer, this study aimed to compare the distribution of common HPV …

Pathomorphological Manifestations and the Course of the Cervical Cancer Disease Determined by Variations in the TLR4 Gene

E Žilienė, A Inčiūra, R Ugenskienė, E Juozaitytė - Diagnostics, 2023 - mdpi.com
Cervical cancer (CC) is often associated with human papillomavirus (HPV). Chronic
inflammation has been described as one of the triggers of cancer. The immune system fights …

Forecasting most deleterious nsSNPs in human TLR9 gene and their cumulative impact on biophysical features of the protein using in silico approaches

H Gautam, VV Verma, SA Husain… - Systems Biology in …, 2023 - Taylor & Francis
In women, the uterine cervix and corpus uteri are two main suspects, playing a major role in
cancer-associated-mortality. Immunologically, Toll-like receptors (TLRs) associated with the …