This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

Iron overload causes progressive organ damage and is associated with arthritis, liver
damage, and heart failure. Elevated iron levels are present in 1%–5% of individuals; …

Neural stem cells are multipotent cells with the ability to differentiate into neurons,
astrocytes, and oligodendrocytes. Lineage specification is strongly sensitive to the …

Kidney fibrosis is the final common pathway of progressive kidney diseases, the underlying
mechanisms of which are not fully understood. The purpose of the current study is to …

Merely touching the pancreas can lead to premature zymogen activation and pancreatitis
but the mechanism is not completely understood. Here we demonstrate that pancreatic …

Cells can respond to mechanical stress by gating mechanosensitive ion channels (MSCs).
The cloning of Piezo1, a eukaryotic cation selective MSC, defines a new system for studying …

Background and Purpose The mechanosensitive Piezo1 channel has important roles in
vascular physiology and disease. Yoda1 is a small‐molecule agonist, but the pharmacology …

Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …

Spiders are the most successful venomous animals and the most abundant terrestrial
predators. Their remarkable success is due in large part to their ingenious exploitation of silk …