Intersection of network medicine and machine learning towards investigating the key biomarkers and pathways underlying amyotrophic lateral sclerosis: a systematic …
Background Network medicine is an emerging area of research that focuses on delving into
the molecular complexity of the disease, leading to the discovery of network biomarkers and …
the molecular complexity of the disease, leading to the discovery of network biomarkers and …
Sporadic amyotrophic lateral sclerosis skeletal muscle transcriptome analysis: a comprehensive examination of differentially expressed genes
E Gascón, P Zaragoza, AC Calvo, R Osta - Biomolecules, 2024 - mdpi.com
Amyotrophic lateral sclerosis (ALS) that comprises sporadic (sALS) and familial (fALS)
cases, is a devastating neurodegenerative disorder characterized by progressive …
cases, is a devastating neurodegenerative disorder characterized by progressive …
A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1G93A model of ALS
D Gerovska, JB Noer, Y Qin, Q Ain, D Januzi… - Cell & Bioscience, 2023 - Springer
Background Numerous genes, including SOD1, mutated in familial and sporadic
amyotrophic lateral sclerosis (f/sALS) share a role in DNA damage and repair, emphasizing …
amyotrophic lateral sclerosis (f/sALS) share a role in DNA damage and repair, emphasizing …
Involvement of ferroptosis in human motor neuron cell death
T Matsuo, K Adachi-Tominari, O Sano, T Kamei… - Biochemical and …, 2021 - Elsevier
Ferroptosis was recently defined as a novel type of programmed cell death depending on
iron and lipid peroxidation. It is biologically different from other types of cell death such as …
iron and lipid peroxidation. It is biologically different from other types of cell death such as …
DNA damage stress-induced translocation of mutant FUS proteins into cytosolic granules and screening for translocation inhibitors
M Nogami, O Sano, K Adachi-Tominari… - Frontiers in Molecular …, 2022 - frontiersin.org
Fused in sarcoma/translated in liposarcoma (FUS) is an RNA-binding protein, and its
mutations are associated with neurodegenerative diseases, including amyotrophic lateral …
mutations are associated with neurodegenerative diseases, including amyotrophic lateral …
Synchronization of fractional-order gene regulatory networks mediated by miRNA with time delays and unknown parameters
YAN Hongyun, Q Yuanhua, D Lijuan, M Jun - Journal of the Franklin …, 2022 - Elsevier
To investigate the regulatory function of miRNA on gene expression at the post-
transcriptional level, the synchronization of fractional-order gene regulatory networks …
transcriptional level, the synchronization of fractional-order gene regulatory networks …
Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis
K Okada, D Ito, S Morimoto, C Kato, Y Oguma, H Warita… - Brain, 2024 - academic.oup.com
Advanced pathological and genetic approaches have revealed that mutations in fused in
sarcoma/translated in liposarcoma (FUS/TLS), which is pivotal for DNA repair, alternative …
sarcoma/translated in liposarcoma (FUS/TLS), which is pivotal for DNA repair, alternative …
From use of omics to systems biology: Identifying therapeutic targets for amyotrophic lateral sclerosis.
L Castelli, R Vasta, SP Allen, R Waller… - International Review …, 2024 - europepmc.org
Amyotrophic lateral sclerosis (ALS) is a heterogeneous progressive neurodegenerative
disorder with available treatments such as riluzole and edaravone extending survival by an …
disorder with available treatments such as riluzole and edaravone extending survival by an …
[HTML][HTML] RNA 結合蛋白質解析の利と美—柔軟かつ堅牢性の高い脳の組織, 細胞機能を包括的に理解する—
矢野真人 - Bulletin of Japanese Society for Neurochemistry, 2022 - neurochem-j.jp
近年の RNA 結合蛋白質研究の歴史は, 2012 年の Castello らの生化学的な mRNA
キャプチャー法 (後述する HITS-CLIP の逆のような方法) などで改めて同定, 精査, 分類され, 2014 …
キャプチャー法 (後述する HITS-CLIP の逆のような方法) などで改めて同定, 精査, 分類され, 2014 …