Lymphatic filariasis and visceral leishmaniasis coinfection: A review on their epidemiology, therapeutic, and immune responses

V Kushwaha, S Kaur - Acta Tropica, 2021 - Elsevier
Coinfection is less commonly observed in individuals around the world, yet it is more
common than the single infection. Around 800 million people worldwide are infected with …

Anti-leishmanial therapy: Caught between drugs and immune targets

H Mahor, A Mukherjee, A Sarkar, B Saha - Experimental Parasitology, 2023 - Elsevier
Leishmaniasis is an enigmatic disease that has very restricted options for chemotherapy and
none for prophylaxis. As a result, deriving therapeutic principles for curing the disease has …

Liposomal formulation of ChimeraT, a multiple T-cell epitope-containing recombinant protein, is a candidate vaccine for human visceral leishmaniasis

DP Lage, PAF Ribeiro, DS Dias, DVC Mendonça… - Vaccines, 2020 - mdpi.com
Background: Leishmaniases are neglected diseases caused by infection with Leishmania
parasites and there are no human vaccines in use routinely. The purpose of this study was …

Intramuscular Immunization with a Liposomal Multi-Epitope Chimeric Protein Induces Strong Cellular Immune Responses against Visceral Leishmaniasis

M Agallou, M Margaroni, E Karagouni - Vaccines, 2023 - mdpi.com
Control of the intracellular parasite Leishmania (L.) requires the activation of strong type 1
cellular immune responses. Towards this goal, in the present study, a multiepitope chimeric …

A Chimera of Th1 Stimulatory Proteins of Leishmania donovani Offers Moderate Immunotherapeutic Efficacy with a Th1‐Inclined Immune Response against Visceral …

S Ratnapriya, Keerti, NK Yadav, A Dube… - BioMed Research …, 2021 - Wiley Online Library
Immunotherapy, a treatment based on host immune system activation, has been shown to
provide a substitute for marginally effective conventional chemotherapy in controlling …

Immunochemotherapy for visceral leishmaniasis: combinatorial action of Miltefosine plus LBSapMPL vaccine improves adaptative Th1 immune response with control …

LM Carvalho, MR Gusmão, AFP Costa, RCF de Brito… - Parasitology, 2022 - cambridge.org
The control of human visceral leishmaniasis (VL) is hard since there are no vaccines
available as well as the treatment is hampered by toxicity and resistant parasites …

Characterization and evaluation of a new triosephosphate isomerase homologue from Haemaphysalis longicornis as a candidate vaccine against tick infection

N Liang, HM Dong, XY Fan, YX Wu, F Yang… - Ticks and Tick-borne …, 2022 - Elsevier
Haemaphysalis longicornis is an obligate hematophagous ectoparasite that transmits a
variety of pathogens causing life‑threatening diseases in humans and animals …

Differential Immune Responses of Th1 Stimulatory Chimeric Antigens of Leishmania donovani in BALB/c Mice

N Gupta, AK Yadav, PK Verma… - ACS Infectious …, 2024 - ACS Publications
Visceral leishmaniasis (VL) is the third most severe infectious parasitic disease and is
caused by the protozoan parasite Leishmania. To control the spread of the disease in …

[HTML][HTML] Combined immunotherapeutic effect of Leishmania-derived recombinant aldolase and Ambisome against experimental visceral leishmaniasis

NK Yadav, S Joshi, S Ratnapriya… - Journal of Microbiology …, 2023 - Elsevier
Background Available therapeutics for visceral leishmaniasis (VL), a deadly parasitic
infection, are usually associated with inadequate efficacy and adverse aftereffects. Further …

Intranasal delivery of LaAg vaccine improves immunity of aged mice against visceral Leishmaniasis

CL Salgado, AFM Corea, LP Covre… - Acta Tropica, 2024 - Elsevier
There are no approved vaccines yet for human visceral leishmaniasis (VL), the most severe
form of the leishmaniasis clinical manifestations that is fatal in over 95% of untreated cases …