Eight types of short-chain Lys acylations have recently been identified on histones:
propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation …

The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a
highly aggressive acute leukaemia associated with poor clinical outcome. The preferential …

The discovery of new histone modifications is unfolding at startling rates; however, the
identification of effectors capable of interpreting these modifications has lagged behind …

Protein post-translational modifications play key roles in multiple cellular processes by
allowing rapid reprogramming of individual protein functions. Acylation, one of the most …

Metabolic signaling to chromatin often underlies how adaptive transcriptional responses are
controlled. While intermediary metabolites serve as co-factors for histone-modifying …

The field of chromatin biology has been advancing at an accelerated pace. Recent
discoveries of previously uncharacterized sites and types of post-translational modifications …

The accessibility of eukaryotic genomes to the action of enzymes involved in transcription,
replication and repair is maintained despite the organization of DNA into nucleosomes. This …

The genomes of all organisms throughout the tree of life are compacted and organized in
chromatin by association of chromatin proteins. Eukaryotic genomes encode histones, which …

Histone acetylation, including acetylated H3K14 (H3K14ac), is generally linked to gene
activation. Monomethylated histone H3 lysine 4 (H3K4me1), together with other gene …