The regulation of PKA signaling in obesity and in the maintenance of metabolic health

E London, CA Stratakis - Pharmacology & therapeutics, 2022 - Elsevier
The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling
pathway throughout systems and across species. PKA facilitates the actions of hormones …

[PDF][PDF] Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy

H Yang, L Yang - J Mol Endocrinol, 2016 - academia.edu
In mammals, cyclic adenosine monophosphate (cAMP) is an intracellular second
messenger that is usually elicited by binding of hormones and neurotransmitters to G protein …

Ellagic acid protects against diabetes-associated behavioral deficits in rats: Possible involved mechanisms

Y Farbood, M Rashno, S Ghaderi, SE Khoshnam… - Life sciences, 2019 - Elsevier
Aims Diabetes mellitus (DM), a chronic metabolic disease, is associated with behavioral
deficits. It has been suggested that ellagic acid (EA), a natural polyphenol compound, has …

Insulin and β adrenergic receptor signaling: crosstalk in heart

Q Fu, Q Wang, YK Xiang - Trends in Endocrinology & Metabolism, 2017 - cell.com
Recent advances show that insulin may affect β adrenergic receptor (βAR) signaling in the
heart to modulate cardiac function in clinically relevant states, such as diabetes mellitus …

Diabetes during pregnancy enhanced neuronal death in the hippocampus of rat offspring

N Lotfi, J Hami, M Hosseini, D Haghir… - International Journal of …, 2016 - Elsevier
Background Diabetes in pregnancy has a detrimental effect on central nervous system
(CNS) development and is associated with an increased risk of short-and long-term …

Novel mutations associated with combined pituitary hormone deficiency

CJ Romero, E Pine-Twaddell… - Journal of molecular …, 2011 - jme.bioscientifica.com
The pituitary gland produces hormones that play important roles in both the development
and the homeostasis of the body. A deficiency of two or several of these pituitary hormones …

Stereological study of the effects of maternal diabetes on cerebellar cortex development in rat

J Hami, S Vafaei-Nezhad, K Ghaemi, A Sadeghi… - Metabolic brain …, 2016 - Springer
Diabetes during pregnancy is associated with the deficits in balance and motor coordination
and altered social behaviors in offspring. In the present study, we have investigated the …

Propranolol treatment lowers blood pressure, reduces vascular inflammatory markers and improves endothelial function in obese mice

N da Silva Franco, C Lubaczeuski, DM Guizoni… - Pharmacological …, 2017 - Elsevier
Obesity-associated hypertension is accompanied by a number of cardiovascular risk factors
including vascular insulin resistance (IR) and higher sympathetic nervous activity. Therefore …

Volumetric investigation of the hippocampus in rat offspring due to diabetes in pregnancy–A stereological study

A Sadeghi, H Asghari, J Hami, MM Roodi… - Journal of chemical …, 2019 - Elsevier
Background The brain development during the prenatal period is affected by various factors,
including the mother's metabolic condition. It has been revealed that diabetes in pregnancy …

[PDF][PDF] Norepinephrine release may play a critical role in the Warburg effect: an integrative model of tumorigenesis

PJ Fitzgerald - Neoplasma, 2020 - researchgate.net
Many cancer cells share the property of carrying out markedly elevated rates of glycolysis to
generate energy even in the presence of sufficient oxygen, and this is known as the Warburg …