Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

Elemental imaging gives insight into the fundamental chemical makeup of living organisms.
Every cell on Earth is comprised of a complex and dynamic mixture of the chemical elements …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Although iron is crucial for neuronal functioning, many aspects of cerebral iron biology await
clarification. The ability to quantify specific iron forms in the living brain would open new …

The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a
central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …

This work reviews the operating principles of ICP-tandem mass spectrometry (ICP-MS/MS)
and the key applications reported on since the introduction of the technique in 2012. The …

Since its inception in the early 80s, inductively coupled plasma–mass spectrometry has
developed to the method of choice for the analysis of elements in complex biological …

Abnormal iron distribution in the isocortex is increasingly recognized as an in vivo marker for
Alzheimer's disease (AD). However, the contribution of iron accumulation to the AD …

Previous MRI studies reported cortical iron accumulation in early-onset (EOAD) compared to
late-onset (LOAD) Alzheimer disease patients. However, the pattern and origin of iron …

Traumatic brain injury (TBI) consists of acute and long-term pathophysiological sequelae
that ultimately lead to cognitive and motor function deficits, with age being a critical risk …