Biomolecular ultrasound and sonogenetics
Visualizing and modulating molecular and cellular processes occurring deep within living
organisms is fundamental to our study of basic biology and disease. Currently, the most …
organisms is fundamental to our study of basic biology and disease. Currently, the most …
[HTML][HTML] State-of-the-art of microbubble-assisted blood-brain barrier disruption
Focused ultrasound with microbubbles promises unprecedented advantages for blood-brain
barrier disruption over existing intracranial drug delivery methods, as well as a significant …
barrier disruption over existing intracranial drug delivery methods, as well as a significant …
Safety and efficacy of focused ultrasound induced blood-brain barrier opening, an integrative review of animal and human studies
Y Meng, CB Pople, H Lea-Banks, A Abrahao… - Journal of controlled …, 2019 - Elsevier
The blood-brain barrier, while fundamental in maintaining homeostasis in the central
nervous system, is a bottleneck to achieving efficacy for numerous therapeutics. Improved …
nervous system, is a bottleneck to achieving efficacy for numerous therapeutics. Improved …
The size of blood–brain barrier opening induced by focused ultrasound is dictated by the acoustic pressure
H Chen, EE Konofagou - Journal of Cerebral Blood Flow & …, 2014 - journals.sagepub.com
Focused ultrasound (FUS) in combination with microbubbles (MBs) has been successfully
used in the delivery of various-size therapeutic agents across the blood–brain barrier (BBB) …
used in the delivery of various-size therapeutic agents across the blood–brain barrier (BBB) …
[HTML][HTML] Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's …
Abstract Rationale: Treatment for Parkinson's disease (PD) is challenged by the presence of
the blood-brain barrier (BBB) that significantly limits the effective drug concentration in a …
the blood-brain barrier (BBB) that significantly limits the effective drug concentration in a …
Cavitation-modulated inflammatory response following focused ultrasound blood-brain barrier opening
Focused ultrasound (FUS) in combination with systemically injected microbubbles can be
used to non-invasively open the blood-brain barrier (BBB) in targeted regions for a variety of …
used to non-invasively open the blood-brain barrier (BBB) in targeted regions for a variety of …
Translation of focused ultrasound for blood-brain barrier opening in glioma
Survival outcomes for patients with glioblastoma multiforme (GBM) have remained poor for
the past 15 years, reflecting a clear challenge in the development of more effective treatment …
the past 15 years, reflecting a clear challenge in the development of more effective treatment …
[HTML][HTML] Advances in ultrasound mediated gene therapy using microbubble contrast agents
Microbubble ultrasound contrast agents have the potential to dramatically improve gene
therapy treatments by enhancing the delivery of therapeutic DNA to malignant tissue. The …
therapy treatments by enhancing the delivery of therapeutic DNA to malignant tissue. The …
Characterization of different microbubbles in assisting focused ultrasound-induced blood-brain barrier opening
Microbubbles (MBs) serve as a critical catalyst to amplify local cavitation in CNS capillary
lumen to facilitate focused ultrasound (FUS) to transiently open the blood-brain barrier …
lumen to facilitate focused ultrasound (FUS) to transiently open the blood-brain barrier …
Clinical gene therapy for neurodegenerative diseases: past, present, and future
Clinical gene therapy has made important advances over the last decade. Among
neurological diseases, severe genetic neurodegenerative conditions have been the focus of …
neurological diseases, severe genetic neurodegenerative conditions have been the focus of …