Alzheimer's disease (AD) is an age-associated neurodegenerative disease; it is the most
common cause of senile dementia. Klotho, a single-pass transmembrane protein primarily …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The organelle of eukaryotes is a finely regulated system. Once disturbed, it activates the
specific autoregulatory systems, namely, organelle autoregulation. Among which, the Golgi …

Immunosenescence in monocytes has been shown to be associated with several
biochemical and functional changes, including development of senescence-associated …

Depression is acknowledged as a major public health problem. Pharmacological treatment
may cause adverse drug reactions and sexual side effects. At the same time, the knowledge …

Cancer is one of the leading causes of death in the modern world. Nowadays, most often
treatment methods used in clinical oncology are drug therapies applied as monotherapy or …

Polycystic ovarian syndrome (PCOS) is frequently observed in adolescent women and
usually progresses with depression. The aim of this study was to examine the effects of …

Amitriptyline (AMI) is a traditional tricyclic antidepressant that has been proven to exhibit
neuroprotective effects in various neurological disorders. However, the underlying …

Abstract α-Klotho is known for its aging-related functions and is associated with
neurodegenerative diseases, accelerated aging, premature morbidity, and mortality. Recent …

Major depressive disorder (MDD) is one of the most prevalent and debilitating psychiatric
disorders, with a large number of patients not showing an effective therapeutic response to …