Design, synthesis, and characterization of (1-(4-aryl)-1 H-1, 2, 3-triazol-4-yl) methyl, substituted phenyl-6-methyl-2-oxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates …

KN Venugopala, GB Dharma Rao… - Drug design …, 2016 - Taylor & Francis
The novel (1-(4-aryl)-1 H-1, 2, 3-triazol-4-yl) methyl, substituted phenyl-6-methyl-2-oxo-1, 2,
3, 4-tetrahydropyrimidine-5-carboxylate derivatives were synthesized by the click reaction of …

Unveiling the impact: A decade review on dihydropyrimidinones (DHPMs) to combat breast cancer

D Nikam, P Chaure, L Dhindale, P Bhagat - Journal of Molecular Structure, 2024 - Elsevier
Breast cancer remains a significant global health concern in women according to IARC 2022
statistics, necessitating the continual exploration of novel therapeutic strategies. Genetic …

In silico design and synthesis of tetrahydropyrimidinones and tetrahydropyrimidinethiones as potential thymidylate kinase inhibitors exerting anti-TB activity against …

KN Venugopala, C Tratrat, M Pillay… - Drug Design …, 2020 - Taylor & Francis
Background and Purpose Tuberculosis has been reported to be the worldwide leading
cause of death resulting from a sole infectious agent. The emergence of multidrug-resistant …

Evaluation of halogenated coumarins for antimosquito properties

VK Narayanaswamy, RM Gleiser… - The Scientific World …, 2014 - Wiley Online Library
Mosquitoes are the major vectors of parasites and pathogens affecting humans and
domestic animals. The widespread development of insecticide resistance and negative …

1,2,3-Triazolyl-tetrahydropyrimidine Conjugates as Potential Sterol Carrier Protein-2 Inhibitors: Larvicidal Activity against the Malaria Vector Anopheles arabiensis …

KN Venugopala, P Shinu, C Tratrat, PK Deb… - Molecules, 2022 - mdpi.com
Alteration of insect growth regulators by the action of inhibitors is becoming an attractive
strategy to combat disease-transmitting insects. In the present study, we investigated the …

[PDF][PDF] Dengue virus disease: Current updates on the use of Carica papaya leaf extract as a potential herbal medicine

NT Mulgund - Int. J. Sci. Res. Innov. Std, 2017 - researchgate.net
This review of literature highlights the potentiality of Carica papaya leaf extract in controlling
dengue viral disease induced thrombocytopenia-platelet count and discussed most of the …

Larvicidal Activities of 2-Aryl-2,3-Dihydroquinazolin -4-ones against Malaria Vector Anopheles arabiensis, In Silico ADMET Prediction and Molecular Target …

KN Venugopala, P Ramachandra, C Tratrat… - Molecules, 2020 - mdpi.com
Malaria, affecting all continents, remains one of the life-threatening diseases introduced by
parasites that are transmitted to humans through the bites of infected Anopheles …

Synthesis, crystal structure and Hirshfeld surface analysis of the 1-(3, 6-dihydropyrimidin-2-yl) urea salt structurally related to dihydropyrimidinon-2-ylurea-type RNA …

A Salinas-Hernández, GE Delgado… - Journal of Molecular …, 2022 - Elsevier
The postmulticomponent synthesis and crystal structure of 1-(3, 6-dihydropyrimidin-2-yl)
urea salt, 5-(ethoxycarbonyl)-4-methyl-6-phenyl-2-ureido-3, 6-dihydropyrimidin-1-ium …

Antidiabetic activity of dihydropyrimidine scaffolds and structural insight by single crystal x-ray studies

KM Bairagi, NS Younis, PM Emeka… - Medicinal …, 2020 - ingentaconnect.com
Background: This research project is designed to identify the anti-diabetic effects of the
newly synthesized compounds to conclude the perspective of consuming one or more of …

Antimycobacterial, docking and molecular dynamic studies of pentacyclic triterpenes from Buddleja saligna leaves

A Singh, KN Venugopala, MA Khedr… - Journal of …, 2017 - Taylor & Francis
Buddleja saligna (family Buddlejaceae) is a medicinal plant endemic to South Africa. Two
isomeric pentacyclic triterpenes, oleanolic acid and ursolic acid, were isolated from the …